Literature DB >> 30367895

TRA2A promotes proliferation, migration, invasion and epithelial mesenchymal transition of glioma cells.

Ying Tan1, Xi Hu2, Yongbing Deng2, Peng Yuan2, Yanfeng Xie3, Jia Wang4.   

Abstract

TRA2A, Transformer2A proteins, plays important roles in paclitaxel resistance and progression of breast cancer. However, whether TRA2A was involved in the progression of glioma remains to be elucidated. In this study, our results demonstrated that the expression of TRA2A was higher in the glioma tissue than that of normal tissue. Overexpression of TRA2A in glioma SHG44 cell lines promoted the tumor cells proliferation, migration, invasion and epithelial mesenchymal transition (EMT), while, knockdown of TRA2A showed the opposite effect. Thus, our findings provide new insights into the role of TRA2A in the progression of glioma, and implicate the potential application of TRA2A in glioma therapy.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  EMT; Glioma; Invasion; Migration; Proliferation; TRA2A

Mesh：

Substances：

Year:  2018        PMID： 30367895     DOI： 10.1016/j.brainresbull.2018.10.006

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  6 in total

1.  Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.

Authors:  Wenpeng Cao; Shan Lei; Zhirui Zeng; Chaolun Xiao; Baofei Sun; Peng Xie; Yumei Li; Daopeng Luo; Wenfeng Yu
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

2.  Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B.

Authors:  Yao Lu; Bo Jiang; Kangli Peng; Shasha Li; Xiangnan Liu; Bufan Wang; Yuntian Chen; Tiepeng Wang; Bo Zhao
Journal:  Front Cell Dev Biol       Date:  2022-05-20

3.  TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.

Authors:  Qianshuo Liu; Lu Zhu; Xiaobai Liu; Jian Zheng; Yunhui Liu; Xuelei Ruan; Shuo Cao; Heng Cai; Zhen Li; Yixue Xue
Journal:  RNA Biol       Date:  2020-05-06       Impact factor: 4.652

4.  In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles.

Authors:  Martin Bartas; Václav Brázda; Natália Bohálová; Alessio Cantara; Adriana Volná; Tereza Stachurová; Kateřina Malachová; Eva B Jagelská; Otília Porubiaková; Jiří Červeň; Petr Pečinka
Journal:  Front Microbiol       Date:  2020-07-03       Impact factor: 5.640

5.  Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasion, migration and epithelial‑mesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to N‑myc downstream regulated gene 1 promoter.

Authors:  Jing Zhang; Yunna Yang; Yipeng Dong; Cang Liu
Journal:  Int J Mol Med       Date:  2021-12-16       Impact factor: 4.101

6.  Analyses of human cancer driver genes uncovers evolutionarily conserved RNA structural elements involved in posttranscriptional control.

Authors:  Van S Tompkins; Warren B Rouse; Collin A O'Leary; Ryan J Andrews; Walter N Moss
Journal:  PLoS One       Date:  2022-02-25       Impact factor: 3.752
  6 in total

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