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Literature DB >> 30364460

The therapeutic role of ivabradine in heart failure.

Charles Badu-Boateng¹, Robert Jennings¹, Daniel Hammersley².

Abstract

Heart failure represents a major global cause of morbidity and mortality. Ivabradine is a selective funny current (If) inhibitor, which acts on the sinoatrial node, resulting in a reduction in heart rate. Ivabradine is currently licensed for use in patients with symptomatic heart failure with reduced ejection fraction and a heart rate persistently at least 70 beats per minute in spite of otherwise optimal prognostic heart failure pharmacotherapy. In this review article, we examine the mechanism of action of ivabradine, evaluate the clinical trials underpinning its application in heart failure and discuss its current recommended clinical use in this capacity.

Entities: Chemical Disease Species

Keywords: drug therapy; heart failure; ivabradine

Year: 2018 PMID： 30364460 PMCID： PMC6196638 DOI： 10.1177/2040622318784556

Source DB: PubMed Journal: Ther Adv Chronic Dis ISSN： 2040-6223 Impact factor: 5.091

52 in total

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4 in total