Gian Pal1, Erin Robertson2, Joan O'Keefe2, Deborah Hall1. 1. Department of Neurological Sciences Rush University Chicago Illinois USA. 2. Department of Anatomy & Cell Biology Rush University Chicago Illinois USA.
Abstract
BACKGROUND: Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the glucocerebrosidase (GBA) gene. METHODS: This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search. RESULTS: There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD-GBA carriers, compared to noncarriers. PD-GBA carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD-GBA carriers may also have a more aggressive motor phenotype than noncarriers. CONCLUSIONS: Early identification of PD-GBA carriers may lead to targeted therapies and development of new treatments.
BACKGROUND: Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the glucocerebrosidase (GBA) gene. METHODS: This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search. RESULTS: There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD-GBA carriers, compared to noncarriers. PD-GBA carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD-GBA carriers may also have a more aggressive motor phenotype than noncarriers. CONCLUSIONS: Early identification of PD-GBA carriers may lead to targeted therapies and development of new treatments.
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