Alessandra Fanciulli1,2, Georg Goebel3, Bernhard Metzler4, Fabienne Sprenger1, Werner Poewe1, Gregor K Wenning1, Klaus Seppi1. 1. Department of Neurology Innsbruck Medical University Innsbruck Austria. 2. Department of Neuroscience Mental Health and Sensory Organs "Sapienza" University of Rome Rome Italy. 3. Department of Medical Statistics Informatics and Health Economics Innsbruck Medical University Innsbruck Austria. 4. Third Department of Internal Medicine Innsbruck Medical University Innsbruck Austria.
Abstract
BACKGROUND AND METHODS: To investigate the possible efficacy of an elastic abdominal binder to control orthostatic hypotension (OH) associated with Parkinson's disease (PD), 15 patients with PD and OH were enrolled in a single-blind crossover study with elastic abdominal versus placebo binder on two different days, separated by a 1-day interval, followed by a 4-week open-label follow-up. RESULTS: Intervention significantly reduced blood pressure fall upon tilting. The mean difference (standard deviation; 95% confidence intervals) between abdominal binder versus placebo was +10 mm Hg (10.2; +3.5, +16.5; P = 0.006). No significant effect on supine mean blood pressure values was observed compared to placebo (P = 0.3). Symptoms of OH decreased significantly during follow-up (P = 0.003), as assessed by means of the Orthostatic Hypotension Questionnaire. CONCLUSIONS: Our findings suggest that elastic abdominal binders may be a simple complementary tool to alleviate OH in PD.
BACKGROUND AND METHODS: To investigate the possible efficacy of an elastic abdominal binder to control orthostatic hypotension (OH) associated with Parkinson's disease (PD), 15 patients with PD and OH were enrolled in a single-blind crossover study with elastic abdominal versus placebo binder on two different days, separated by a 1-day interval, followed by a 4-week open-label follow-up. RESULTS: Intervention significantly reduced blood pressure fall upon tilting. The mean difference (standard deviation; 95% confidence intervals) between abdominal binder versus placebo was +10 mm Hg (10.2; +3.5, +16.5; P = 0.006). No significant effect on supine mean blood pressure values was observed compared to placebo (P = 0.3). Symptoms of OH decreased significantly during follow-up (P = 0.003), as assessed by means of the Orthostatic Hypotension Questionnaire. CONCLUSIONS: Our findings suggest that elastic abdominal binders may be a simple complementary tool to alleviate OH in PD.
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