Andrés Catzín-Kuhlmann1, Alma Juárez-Armenta2, Eduardo Ortiz-Panozo2, Adriana Monge-Urrea2, Karl P Puchner2,3, Carlos Cantú-Brito4, Ruy López-Ridaura2, Megan S Rice5,6, Tobias Kurth7,8, Martín Lajous2,9. 1. Department of Medicine National Institute of Medical Sciences and Nutrition Mexico City Mexico. 2. Center for Research on Population Health National Institute of Public Health Cuernavaca Mexico. 3. Institute of Tropical Medicine and International Health Charité-Universitätsmedizin Berlin Germany. 4. Department of Neurology and Psychiatry National Institute of Medical Sciences and Nutrition Mexico City Mexico. 5. Department of Epidemiology Harvard School of Public Health Boston Massachusetts USA. 6. Channing Division of Network Medicine Brigham & Women's Hospital Boston Massachusetts USA. 7. Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology Bordeaux France. 8. University of Bordeaux Bordeaux France. 9. Inserm, Center for Research in Epidemiology and Population Health (CESP) U1018 Gustave-Roussy Cancer Institute Villejuif France.
Abstract
BACKGROUND: RLS is a common chronic disorder characterized by an irresistible need to move the lower limbs that affects sleep. Poor sleep has been associated with increased blood pressure (BP). Thus, we evaluated the cross-sectional relationship between RLS and hypertension (HTN) in a large cohort study in Mexico. METHODS: In 2011, 54,925 female participants from the Mexican Teachers' Cohort responded to a four-item questionnaire based on the International Restless Legs Syndrome Study Group's minimal diagnostic criteria. Women also reported diagnosis and treatment of HTN. We used multivariable logistic regression models to estimate prevalence odds ratios (ORs) for HTN, adjusting for lifestyle and dietary factors. We also estimated adjusted prevalence ORs for HTN by frequency of RLS symptoms. RESULTS: We identified 9,230 cases (17%) of RLS, and the prevalence of HTN was 13.1% among women with RLS and 9.4% among those without RLS. The multivariable-adjusted prevalence OR for HTN comparing women with to those without RLS was 1.18 (95% confidence interval [CI]: 1.10-1.26). Compared to those without RLS, the prevalence OR of HTN in women reporting a symptom frequency of once a month or less was 1.14 (95% CI: 1.00-1.30); among those with symptoms two to four times a month, the OR was 1.17 (95% CI: 1.05-1.30); and for those with symptoms at least two times a week, the OR was 1.22 (95% CI: 1.10-1.35). CONCLUSION: We observed an association between RLS and HTN. Future studies should evaluate the impact of treating RLS on BP.
BACKGROUND: RLS is a common chronic disorder characterized by an irresistible need to move the lower limbs that affects sleep. Poor sleep has been associated with increased blood pressure (BP). Thus, we evaluated the cross-sectional relationship between RLS and hypertension (HTN) in a large cohort study in Mexico. METHODS: In 2011, 54,925 female participants from the Mexican Teachers' Cohort responded to a four-item questionnaire based on the International Restless Legs Syndrome Study Group's minimal diagnostic criteria. Women also reported diagnosis and treatment of HTN. We used multivariable logistic regression models to estimate prevalence odds ratios (ORs) for HTN, adjusting for lifestyle and dietary factors. We also estimated adjusted prevalence ORs for HTN by frequency of RLS symptoms. RESULTS: We identified 9,230 cases (17%) of RLS, and the prevalence of HTN was 13.1% among women with RLS and 9.4% among those without RLS. The multivariable-adjusted prevalence OR for HTN comparing women with to those without RLS was 1.18 (95% confidence interval [CI]: 1.10-1.26). Compared to those without RLS, the prevalence OR of HTN in women reporting a symptom frequency of once a month or less was 1.14 (95% CI: 1.00-1.30); among those with symptoms two to four times a month, the OR was 1.17 (95% CI: 1.05-1.30); and for those with symptoms at least two times a week, the OR was 1.22 (95% CI: 1.10-1.35). CONCLUSION: We observed an association between RLS and HTN. Future studies should evaluate the impact of treating RLS on BP.
Authors: Anke C Winter; Klaus Berger; Robert J Glynn; Julie E Buring; J Michael Gaziano; Markus Schürks; Tobias Kurth Journal: Am J Med Date: 2013-03 Impact factor: 4.965
Authors: Anke C Winter; Markus Schürks; Robert J Glynn; Julie E Buring; J Michael Gaziano; Klaus Berger; Tobias Kurth Journal: Am J Med Date: 2013-03 Impact factor: 4.965
Authors: G Giannini; S Zanigni; R Melotti; M Gögele; F Provini; M F Facheris; P Cortelli; P P Pramstaller Journal: Eur J Neurol Date: 2013-07-30 Impact factor: 6.089
Authors: Mauro Manconi; Raffaele Ferri; Marco Zucconi; Stefan Clemens; Francesco Rundo; Alessandro Oldani; Luigi Ferini-Strambi Journal: Sleep Med Date: 2010-09-17 Impact factor: 3.492