Literature DB >> 3036303

Different postnatal ontogeny of two [3H]neurotensin binding sites in rat brain.

A Schotte, P M Laduron.   

Abstract

Two distinct neurotensin binding sites have been identified in rat brain: the NT1-acceptor site (levocabastine-sensitive) and the NT2-receptor site. In rat forebrain, NT2-receptors were present at birth, revealed a maximal level (13.8 fmol/mg tissue) on day 10 of postnatal life but a much lower plateau (3.0 fmol/mg tissue) in adult rats. NT1-acceptors were not detected before day 10 and became maximal at day 30. It is suggested that the loss of NT2-receptor sites during the postnatal development may be the expression of the regression of a transient redundancy of neuronal connections.

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Year:  1987        PMID： 3036303     DOI： 10.1016/0006-8993(87)90398-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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Authors:  T Croci; G Aureggi; F Guagnini; L Manara; D Gully; G L Fur; J P Maffrand; S Mukenge; G Ferla; P Ferrara; P Chalon; N Vita
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

2.  Existence of two translation initiation sites leading to the expression of two proteins from the rat high-affinity neurotensin-receptor cDNA: possible regulation by the 5' end non-coding region.

Authors:  J M Botto; J P Vincent; J Mazella
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

3.  Differential binding profile and internalization process of neurotensin via neuronal and glial receptors.

Authors:  D Nouel; M P Faure; J A St Pierre; R Alonso; R Quirion; A Beaudet
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

Review 4.  Neurotensin receptors: binding properties, transduction pathways, and structure.

Authors:  J P Vincent
Journal:  Cell Mol Neurobiol       Date:  1995-10       Impact factor: 5.046

5.  Regulation of the neurotensin NT(1) receptor in the developing rat brain following chronic treatment with the antagonist SR 48692.

Authors:  I Lépée-Lorgeoux; C Betancur; F Souazé; W Rostène; A Bérod; D Pélaprat
Journal:  J Neurosci Res       Date:  2000-05-01       Impact factor: 4.164

6.  Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.

Authors:  J Mazella; J M Botto; E Guillemare; T Coppola; P Sarret; J P Vincent
Journal:  J Neurosci       Date:  1996-09-15       Impact factor: 6.167

7.  Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Authors:  Geneviève Roussy; Marc-André Dansereau; Stéphanie Baudisson; Faouzi Ezzoubaa; Karine Belleville; Nicolas Beaudet; Jean Martinez; Elliott Richelson; Philippe Sarret
Journal:  Mol Pain       Date:  2009-07-06       Impact factor: 3.395

8.  Developmental dynamics of neurotensin binding sites in the human hypothalamus during the first postnatal year.

Authors:  Mohamed Najimi; Alain Sarrieau; Nicolas Kopp; Fatiha Chigr
Journal:  Front Cell Neurosci       Date:  2014-09-10       Impact factor: 5.505
  8 in total

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