Literature DB >> 3036283

Evidence for endothelium-dependent vasodilation of resistance vessels by acetylcholine.

R F Furchgott, M H Carvalho, M T Khan, K Matsunaga.   

Abstract

In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of the vasculature with 0.2% collagenase, an enzyme capable of removing endothelial cells. In the perfused mesenteric arterial vasculature of the rat, vasodilation by ACh was markedly, though not completely, inhibited by hemoglobin (10 microM), an agent which can inactivate endothelium-derived relaxing factor (EDRF). These results suggest that a major component of vasodilation of mesenteric resistance vessels in rabbit and rat by ACh is mediated by EDRF.

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Year:  1987        PMID： 3036283     DOI： 10.1159/000158689

Source DB:  PubMed          Journal:  Blood Vessels        ISSN： 0303-6847


  29 in total

Review 1.  cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.

Authors:  Sharron H Francis; Jennifer L Busch; Jackie D Corbin; David Sibley
Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

2.  Influence of pressure alterations on tone and vasomotion of isolated mesenteric small arteries of the rat.

Authors:  E VanBavel; M J Giezeman; T Mooij; J A Spaan
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

3.  Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production.

Authors:  Yipin Zhou; Pedro Cabrales; Andre F Palmer
Journal:  Biophys Chem       Date:  2012-01-09       Impact factor: 2.352

4.  Impaired forearm vasodilatation by acetylcholine in patients with hypertension.

Authors:  M Yoshida; T Imaizumi; S Ando; Y Hirooka; S Harada; A Takeshita
Journal:  Heart Vessels       Date:  1991       Impact factor: 2.037

5.  EDRF-mediated dilatation in the rat isolated perfused kidney: a microangiographic study.

Authors:  G A Burton; T M Griffith; D H Edwards
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

Review 6.  GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.

Authors:  Alessandro Cannavo; Walter J Koch
Journal:  Cell Signal       Date:  2017-01-07       Impact factor: 4.315

7.  Elevated guanosine 3':5'-cyclic monophosphate mediates the depression of nitrovasodilator reactivity in endothelium-intact blood vessels.

Authors:  W F Jackson; R Busse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-09       Impact factor: 3.000

8.  Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists.

Authors:  T D Warner
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

9.  Endothelium-derived relaxing factor and the effects of acetylcholine and histamine on resistance blood vessels.

Authors:  R Bhardwaj; P K Moore
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

Review 10.  Endothelium-derived relaxing factor and the pulmonary circulation.

Authors:  G Cremona; A T Dinh Xuan; T W Higenbottam
Journal:  Lung       Date:  1991       Impact factor: 2.584
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