Yago Leira1,2, Manuel Rodríguez-Yáñez3, Susana Arias3, Iria López-Dequidt3, Francisco Campos3, Tomás Sobrino3, Francesco D'Aiuto2, José Castillo3, Juan Blanco1. 1. Periodontology Unit, Faculty of Medicine and Odontology, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain. 2. Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, London, UK. 3. Clinical Neurosciences Research Laboratory, Department of Neurology, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Abstract
AIM: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI. MATERIAL AND METHODS: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. In addition, a measure of periodontal inflammation and disease activity, namely the periodontal inflamed surface area (PISA), was also calculated for each patient. Poor functional outcome was considered as a modified Rankin Scale >2 at 3 months. RESULTS: PD was independently associated with the presence of LI (OR = 3.3, p < 0.001). Poor outcome was observed in 31 patients with LI (25.8%), of which 90.3% had PD. A PISA value ≥727 mm2 was an independent predictor of poor prognosis, after adjusting for clinical confounders (OR = 6.5, p = 0.001). CONCLUSIONS: PD and LI were associated. Active moderate to severe PD predicted poor prognosis in patients with LI. Further evidence is warranted to confirm our results and investigate potential mechanisms behind this association.
AIM: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI. MATERIAL AND METHODS: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. In addition, a measure of periodontal inflammation and disease activity, namely the periodontal inflamed surface area (PISA), was also calculated for each patient. Poor functional outcome was considered as a modified Rankin Scale >2 at 3 months. RESULTS:PD was independently associated with the presence of LI (OR = 3.3, p < 0.001). Poor outcome was observed in 31 patients with LI (25.8%), of which 90.3% had PD. A PISA value ≥727 mm2 was an independent predictor of poor prognosis, after adjusting for clinical confounders (OR = 6.5, p = 0.001). CONCLUSIONS:PD and LI were associated. Active moderate to severe PD predicted poor prognosis in patients with LI. Further evidence is warranted to confirm our results and investigate potential mechanisms behind this association.
Authors: Yago Leira; Pablo Ameijeira; Clara Domínguez; Esteban López-Arias; Paulo Ávila-Gómez; María Pérez-Mato; Tomás Sobrino; Francisco Campos; Francesco D'Aiuto; Rogelio Leira; Juan Blanco Journal: Clin Oral Investig Date: 2019-05-20 Impact factor: 3.573
Authors: Rizky A Irwandi; Scott T Chiesa; George Hajishengallis; Venizelos Papayannopoulos; John E Deanfield; Francesco D'Aiuto Journal: Front Immunol Date: 2022-07-07 Impact factor: 8.786
Authors: Yago Leira; Paulo Mascarenhas; Juan Blanco; Tomás Sobrino; José João Mendes; Vanessa Machado; João Botelho Journal: Genes (Basel) Date: 2021-05-20 Impact factor: 4.096