Rossella Alfano1, Zdenko Herceg2, Tim S Nawrot1,3, Marc Chadeau-Hyam4, Akram Ghantous5, Michelle Plusquin6. 1. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. 2. Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, 69008, Lyon, France. 3. Environment & Health Unit, Leuven University, Leuven, Belgium. 4. Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK. 5. Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, 69008, Lyon, France. GhantousA@iarc.fr. 6. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. michelle.plusquin@uhasselt.be.
Abstract
PURPOSE OF REVIEW: This systematic review evaluated existing evidence linking air pollution exposure in humans to major epigenetic mechanisms: DNA methylation, microRNAs, long noncoding RNAs, and chromatin regulation. RECENT FINDINGS: Eighty-two manuscripts were eligible, most of which were observational (85%), conducted in adults (66%) and based on DNA methylation (79%). Most observational studies, except panel, demonstrated modest effects of air pollution on the methylome. Panel and experimental studies revealed a relatively large number of significant methylome alterations, though based on smaller sample sizes. Particulate matter levels were positively associated in several studies with global or LINE-1 hypomethylation, a hallmark of several diseases, and with decondensed chromatin structure. Several air pollution species altered the DNA methylation clock, inducing accelerated biological aging. The causal nature of identified associations is not clear, however, especially that most originate from countries with low air pollution levels. Existing evidence, gaps, and perspectives are highlighted herein.
PURPOSE OF REVIEW: This systematic review evaluated existing evidence linking air pollution exposure in humans to major epigenetic mechanisms: DNA methylation, microRNAs, long noncoding RNAs, and chromatin regulation. RECENT FINDINGS: Eighty-two manuscripts were eligible, most of which were observational (85%), conducted in adults (66%) and based on DNA methylation (79%). Most observational studies, except panel, demonstrated modest effects of air pollution on the methylome. Panel and experimental studies revealed a relatively large number of significant methylome alterations, though based on smaller sample sizes. Particulate matter levels were positively associated in several studies with global or LINE-1 hypomethylation, a hallmark of several diseases, and with decondensed chromatin structure. Several air pollution species altered the DNA methylation clock, inducing accelerated biological aging. The causal nature of identified associations is not clear, however, especially that most originate from countries with low air pollution levels. Existing evidence, gaps, and perspectives are highlighted herein.
Entities:
Keywords:
Air pollution; Chromatin; DNA methylation; Epigenetics; MicroRNAs; Noncoding RNA
Authors: Allen S Yang; Marcos R H Estécio; Ketan Doshi; Yutaka Kondo; Eloiza H Tajara; Jean-Pierre J Issa Journal: Nucleic Acids Res Date: 2004-02-18 Impact factor: 16.971
Authors: T Lanki; J Pekkanen; P Aalto; R Elosua; N Berglind; D D'Ippoliti; M Kulmala; F Nyberg; A Peters; S Picciotto; V Salomaa; J Sunyer; P Tiittanen; S von Klot; F Forastiere Journal: Occup Environ Med Date: 2006-08-15 Impact factor: 4.402
Authors: Julian Krauskopf; Florian Caiment; Karin van Veldhoven; Marc Chadeau-Hyam; Rudy Sinharay; Kian Fan Chung; Paul Cullinan; Peter Collins; Benjamin Barratt; Frank J Kelly; Roel Vermeulen; Paolo Vineis; Theo M de Kok; Jos C Kleinjans Journal: Environ Int Date: 2018-01-28 Impact factor: 9.621
Authors: Thomas Thum; Carina Gross; Jan Fiedler; Thomas Fischer; Stephan Kissler; Markus Bussen; Paolo Galuppo; Steffen Just; Wolfgang Rottbauer; Stefan Frantz; Mirco Castoldi; Jürgen Soutschek; Victor Koteliansky; Andreas Rosenwald; M Albert Basson; Jonathan D Licht; John T R Pena; Sara H Rouhanifard; Martina U Muckenthaler; Thomas Tuschl; Gail R Martin; Johann Bauersachs; Stefan Engelhardt Journal: Nature Date: 2008-11-30 Impact factor: 49.962
Authors: Catherine L Callahan; Matthew R Bonner; Jing Nie; Daikwon Han; Youjin Wang; Meng-Hua Tao; Peter G Shields; Catalin Marian; Kevin H Eng; Maurizio Trevisan; Jan Beyea; Jo L Freudenheim Journal: Environ Res Date: 2018-02 Impact factor: 6.498
Authors: Jamaji C Nwanaji-Enwerem; Elena Colicino; Letizia Trevisi; Itai Kloog; Allan C Just; Jincheng Shen; Kasey Brennan; Alexandra Dereix; Lifang Hou; Pantel Vokonas; Joel Schwartz; Andrea A Baccarelli Journal: Environ Epigenet Date: 2016-06-12
Authors: Nelly D Saenen; Karen Vrijens; Bram G Janssen; Harry A Roels; Kristof Y Neven; Wim Vanden Berghe; Wilfried Gyselaers; Charlotte Vanpoucke; Wouter Lefebvre; Patrick De Boever; Tim S Nawrot Journal: Environ Health Perspect Date: 2016-09-13 Impact factor: 9.031
Authors: Gillian C Goobie; Mehdi Nouraie; Yingze Zhang; Daniel J Kass; Christopher J Ryerson; Christopher Carlsten; Kerri A Johannson Journal: Am J Respir Crit Care Med Date: 2020-11-01 Impact factor: 21.405
Authors: Hao Chen; Siqi Zhang; Bin Yu; Yunan Xu; Ana G Rappold; David Diaz-Sanchez; James M Samet; Haiyan Tong Journal: Ecotoxicol Environ Saf Date: 2022-05-13 Impact factor: 7.129
Authors: N D Saenen; D S Martens; K Y Neven; R Alfano; H Bové; B G Janssen; H A Roels; M Plusquin; K Vrijens; T S Nawrot Journal: Clin Epigenetics Date: 2019-09-17 Impact factor: 6.551
Authors: Ikenna C Eze; Ayoung Jeong; Emmanuel Schaffner; Faisal I Rezwan; Akram Ghantous; Maria Foraster; Danielle Vienneau; Florian Kronenberg; Zdenko Herceg; Paolo Vineis; Mark Brink; Jean-Marc Wunderli; Christian Schindler; Christian Cajochen; Martin Röösli; John W Holloway; Medea Imboden; Nicole Probst-Hensch Journal: Environ Health Perspect Date: 2020-06-01 Impact factor: 9.031