Literature DB >> 30361802

Sexual dimorphism in solid and hematological malignancies.

Isabel Ben-Batalla1,2, María Elena Vargas-Delgado1,2, Lara Meier1,2, Sonja Loges3,4.   

Abstract

Cancer represents a leading cause of death with continuously increasing incidence worldwide. Many solid cancer types in non-reproductive organs are significantly more frequent and deadly in males compared to females. This sex-biased difference is also present in hematologic malignancies. In this review, we present an overview about sex differences in cancer with a focus on leukemia. We discuss mechanisms potentially underlying the observed sex-biased imbalance in cancer incidence and outcome including sex hormones, sex chromosomes, and immune responses. Besides affecting the pathobiology of cancers, sex differences can also influence drug responses, most notably those to immune checkpoint blockers. Therefore, sex should become a relevant factor in clinical trial design in order to avoid over- or under-treatment of one sex.

Entities:  

Keywords:  Immune system; Leukemia; Sex difference; Sex hormones

Mesh：

Substances：

Year:  2018        PMID： 30361802     DOI： 10.1007/s00281-018-0724-7

Source DB:  PubMed          Journal:  Semin Immunopathol        ISSN： 1863-2297            Impact factor:   9.623


  133 in total

1.  Re: Brain Feminization Requires Active Repression of Masculinization via DNA Methylation.

Authors:  Anthony Atala
Journal:  J Urol       Date:  2015-09-05       Impact factor: 7.450

2.  Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.

Authors:  S P Shriver; H A Bourdeau; C T Gubish; D L Tirpak; A L Davis; J D Luketich; J M Siegfried
Journal:  J Natl Cancer Inst       Date:  2000-01-05       Impact factor: 13.506

3.  Gender disparity of hepatocellular carcinoma: the roles of sex hormones.

Authors:  Shiou-Hwei Yeh; Pei-Jer Chen
Journal:  Oncology       Date:  2010-07-08       Impact factor: 2.935

4.  Gonadotropin-releasing hormone antagonist in the management of prostate cancer.

Authors:  Frans M J Debruyne
Journal:  Rev Urol       Date:  2004

5.  Potential role of human growth hormone in melanoma growth promotion.

Authors:  Marc Z Handler; Andrew L Ross; Michael I Shiman; George W Elgart; James M Grichnik
Journal:  Arch Dermatol       Date:  2012-10

6.  Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis.

Authors:  C Wallrapp; S Hähnel; W Boeck; A Soder; A Mincheva; P Lichter; G Leder; F Gansauge; C Sorio; A Scarpa; T M Gress
Journal:  Int J Cancer       Date:  2001-02-01       Impact factor: 7.396

7.  Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group.

Authors:  Jason Canner; Todd A Alonzo; Janet Franklin; David R Freyer; Alan Gamis; Robert B Gerbing; Beverly J Lange; Soheil Meshinchi; William G Woods; John Perentesis; John Horan
Journal:  Cancer       Date:  2013-09-19       Impact factor: 6.860

8.  Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.

Authors:  Carlos le Sage; Remco Nagel; David A Egan; Mariette Schrier; Elly Mesman; Annunziato Mangiola; Corrado Anile; Giulio Maira; Neri Mercatelli; Silvia Anna Ciafrè; Maria Giulia Farace; Reuven Agami
Journal:  EMBO J       Date:  2007-07-12       Impact factor: 11.598

9.  Ethnic patterns of Hodgkin's disease incidence among children and adolescents in the United States, 1973-82.

Authors:  M R Spitz; J G Sider; C C Johnson; J J Butler; E S Pollack; G R Newell
Journal:  J Natl Cancer Inst       Date:  1986-02       Impact factor: 13.506

Review 10.  Macrophage cytokines: involvement in immunity and infectious diseases.

Authors:  Guillermo Arango Duque; Albert Descoteaux
Journal:  Front Immunol       Date:  2014-10-07       Impact factor: 7.561
View more
  7 in total

1.  Sex differences in immunity.

Authors:  Hanna Lotter; Marcus Altfeld
Journal:  Semin Immunopathol       Date:  2019-02-11       Impact factor: 9.623

Review 2.  Immune Sexual Dimorphism: Connecting the Dots.

Authors:  Shani Talia Gal-Oz; Tal Shay
Journal:  Physiology (Bethesda)       Date:  2021-09-13

Review 3.  Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer.

Authors:  Isabel Ben-Batalla; María Elena Vargas-Delgado; Gunhild von Amsberg; Melanie Janning; Sonja Loges
Journal:  Front Immunol       Date:  2020-07-02       Impact factor: 7.561

4.  Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice.

Authors:  Eui-Young So; Euy-Myoung Jeong; Keith Q Wu; Patrycja M Dubielecka; Anthony M Reginato; Peter J Quesenberry; Olin D Liang
Journal:  Aging (Albany NY)       Date:  2020-12-09       Impact factor: 5.682

5.  Effects of Clinicopathological Characteristics on the Survival of Patients Treated with PD-1/PD-L1 Inhibitor Monotherapy or Combination Therapy for Advanced Cancer: A Systemic Review and Meta-Analysis.

Authors:  Yuhan Wei; Yongfu Li; Qi Du; Xinyi Peng; Jiangtao Jin; Hong Guo; Yongyan Li; Qin Li
Journal:  J Immunol Res       Date:  2020-12-18       Impact factor: 4.818

Review 6.  The Relevance of Gender in Tumor-Influencing Epigenetic Traits.

Authors:  Victoria Sarne; Sandrina Braunmueller; Lisa Rakob; Rita Seeboeck
Journal:  Epigenomes       Date:  2019-01-28

7.  Hematological Effects and Benchmark Doses of Long-Term Co-Exposure to Benzene, Toluene, and Xylenes in a Follow-Up Study on Petrochemical Workers.

Authors:  Zhaorui Zhang; Xin Liu; Chaofan Guo; Xinjie Zhang; Yingying Zhang; Na Deng; Guanchao Lai; Aichu Yang; Yongshun Huang; Shanfeng Dang; Yanqun Zhu; Xiumei Xing; Yongmei Xiao; Qifei Deng
Journal:  Toxics       Date:  2022-08-28
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.