Giulia Ottaviani1, Katia Rupel1, Margherita Gobbo1, Augusto Poropat1, Valentina Zoi1, Michela Faraon2, Roberto Di Lenarda1, Matteo Biasotto3. 1. Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy. 2. Maxillo-facial and Stomatological Unit, Azienda per l'Assistenza Sanitaria n. 5, Friuli Occidentale, Pordenone Hospital, Pordenone, Italy. 3. Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy. m.biasotto@fmc.units.it.
Abstract
OBJECTIVES: This preliminary randomized double-blind controlled trial was performed to test the efficacy of ultramicronized palmitoylethanolamide treatment in the burning mouth syndrome. MATERIALS AND METHODS: Patients with referred burning mouth intensity greater than 4, according to the Numeric Rating Scale, were included in the study according to established inclusion and exclusion criteria. Patients were randomized into two groups and received either placebo or ultramicronized palmitoylethanolamide 600 mg twice daily for 60 days. Patients were assessed at baseline, 30 and 60 days after treatment start, and 4 months after treatment discontinuation. In order to evaluate the change in the burning mouth sensation over time, the generalized linear mixed model was employed. RESULTS: A total of 35 patients were considered eligible, among which 6 withdrew prior to the end of treatment. A statistically significant reduction of burning mouth sensation (p < 0.0132) was registered at the end of the active treatment in the ultramicronized palmitoylethanolamide group compared to the placebo one. Any side effect related to the active treatment was neither observed nor reported both by patients and by physicians. CONCLUSIONS: The significant decrease of burning sensation in the ultramicronized palmitoylethanolamide group compared to the placebo group suggests to consider this naturally occurring molecule as a viable therapy in the management of burning mouth syndrome. CLINICAL RELEVANCE: The use of an effective compound to manage the burning mouth syndrome, devoid of adverse effects for the patient and that does not interfere with other pharmacological therapies, could find wide employability from clinicians.
RCT Entities:
OBJECTIVES: This preliminary randomized double-blind controlled trial was performed to test the efficacy of ultramicronized palmitoylethanolamide treatment in the burning mouth syndrome. MATERIALS AND METHODS:Patients with referred burning mouth intensity greater than 4, according to the Numeric Rating Scale, were included in the study according to established inclusion and exclusion criteria. Patients were randomized into two groups and received either placebo or ultramicronized palmitoylethanolamide 600 mg twice daily for 60 days. Patients were assessed at baseline, 30 and 60 days after treatment start, and 4 months after treatment discontinuation. In order to evaluate the change in the burning mouth sensation over time, the generalized linear mixed model was employed. RESULTS: A total of 35 patients were considered eligible, among which 6 withdrew prior to the end of treatment. A statistically significant reduction of burning mouth sensation (p < 0.0132) was registered at the end of the active treatment in the ultramicronized palmitoylethanolamide group compared to the placebo one. Any side effect related to the active treatment was neither observed nor reported both by patients and by physicians. CONCLUSIONS: The significant decrease of burning sensation in the ultramicronized palmitoylethanolamide group compared to the placebo group suggests to consider this naturally occurring molecule as a viable therapy in the management of burning mouth syndrome. CLINICAL RELEVANCE: The use of an effective compound to manage the burning mouth syndrome, devoid of adverse effects for the patient and that does not interfere with other pharmacological therapies, could find wide employability from clinicians.
Authors: Satu K Jääskeläinen; Juha O Rinne; Heli Forssell; Olli Tenovuo; Valtteri Kaasinen; Pirkko Sonninen; Jörgen Bergman Journal: Pain Date: 2001-02-15 Impact factor: 6.961
Authors: Nora Hagelberg; Heli Forssell; Sargo Aalto; Juha O Rinne; Harry Scheinin; Tero Taiminen; Kjell Någren; Olli Eskola; Satu K Jääskeläinen Journal: Pain Date: 2003-11 Impact factor: 6.961