Literature DB >> 3036131

The basic glutathione S-transferases from human livers are products of separate genes.

D M Rhoads, R P Zarlengo, C P Tu.   

Abstract

We have characterized a second cDNA sequence, pGTH2, for the human liver glutathione S-transferases Ha subunits. It is 95% homologous base-for-base to the Ha subunit 1 cDNA, pGTH1, except for its longer 3' noncoding sequences. Our results indicate that the multiple basic human liver glutathione S-transferases are products of separate genes. The proposal [Kamisaka, K., Habig, W. H., Ketley, J. N., Arias, I. M., and Jakoby, W. B. (1975) Eur. J. Biochem. 60, 153-161] that deamidation may be a physiologically important process for generating glutathione S-transferases isozyme multiplicity can be all but ruled out.

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Year:  1987        PMID： 3036131     DOI： 10.1016/0006-291x(87)91345-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  25 in total

1.  Cloning and expression of a chick liver glutathione S-transferase CL 3 subunit with the use of a baculovirus expression system.

Authors:  L H Chang; J Y Fan; L F Liu; S P Tsai; M F Tam
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857

2.  Cloning, sequencing and characterization of the human alpha glutathione S-transferase gene corresponding to the cDNA clone pGTH2.

Authors:  A Klöne; R Hussnätter; H Sies
Journal:  Biochem J       Date:  1992-08-01       Impact factor: 3.857

3.  Nomenclature for human glutathione transferases.

Authors:  B Mannervik; Y C Awasthi; P G Board; J D Hayes; C Di Ilio; B Ketterer; I Listowsky; R Morgenstern; M Muramatsu; W R Pearson
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

4.  Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds.

Authors:  G Stenberg; M Ridderström; A Engström; S E Pemble; B Mannervik
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

5.  Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other Alpha class glutathione S-transferases.

Authors:  J D Hayes; L A Kerr; A D Cronshaw
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

6.  Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi.

Authors:  M Q Islam; A Platz; J Szpirer; C Szpirer; G Levan; B Mannervik
Journal:  Hum Genet       Date:  1989-07       Impact factor: 4.132

7.  Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.

Authors:  P G Board
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

8.  Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases.

Authors:  P Alin; H Jensson; E Cederlund; H Jörnvall; B Mannervik
Journal:  Biochem J       Date:  1989-07-15       Impact factor: 3.857

9.  Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

Authors:  J Seidegård; W R Vorachek; R W Pero; W R Pearson
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Genomic organization, 5'-flanking region and chromosomal localization of the human glutathione transferase A4 gene.

Authors:  F Desmots; C Rauch; C Henry; A Guillouzo; F Morel
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857
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