Alfonso Fasano1, Carlo Di Bonaventura2, Francesco Bove3, Alberto J Espay4, Francesca Morgante5, Giovanni Fabbrini6, Renato P Munhoz7, Danielle Andrade8, Felipe Borlot9, Esther Bui10, Giancarlo Di Gennaro11, Raffaele Iorio3, Hans Katzberg12, Marco Luigetti3, Pasquale Striano13, Giovanni Defazio14, Alfredo Berardelli6. 1. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada. Electronic address: alfonso.fasano@gmail.com. 2. Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. 3. Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Neurologia, Rome, Italy; Institute of Neurology, Università Cattolica del Sacro Cuore, Italy. 4. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. 5. Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK. 6. Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy; IRCSS Neuromed, Pozzilli, IS, Italy. 7. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada; Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada. 8. Krembil Brain Institute, Toronto, Ontario, Canada; Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, Ontario, Canada. 9. Division of Neurology, Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada. 10. Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, Ontario, Canada. 11. IRCSS Neuromed, Pozzilli, IS, Italy. 12. Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital and Division of Neurology, University of Toronto, Toronto, Ontario, Canada. 13. Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, "G. Gaslini" Institute, Genova, Italy. 14. Department of Medical Science and Public Health, Neurology Unit, University of Cagliari, Italy.
Abstract
INTRODUCTION: Although focal motor seizures may resemble one or more movement disorders their phenomenology and prevalence remain uncertain. METHODS: To examine the extent to which focal motor seizures can present with a phenomenology fulfilling diagnostic criteria for movement disorders, 100 consecutive patients with focal motor seizures were rated by movement disorders experts, epileptologists, and general neurologists. RESULTS: A focal motor seizure phenomenologically manifested as a defined movement disorder in 29% of the patients from a consecutive video-EEG documented cohort as per consensus among experts: myoclonus and dystonia (10 and 9 cases, respectively) were the most common movement disorders, followed by chorea (4), stereotypies (3) myoclonus-dystonia (2), and tremor (1). CONCLUSIONS: Movement disorders and focal motor epilepsy share overlapping movement phenomenology.
INTRODUCTION: Although focal motor seizures may resemble one or more movement disorders their phenomenology and prevalence remain uncertain. METHODS: To examine the extent to which focal motor seizures can present with a phenomenology fulfilling diagnostic criteria for movement disorders, 100 consecutive patients with focal motor seizures were rated by movement disorders experts, epileptologists, and general neurologists. RESULTS: A focal motor seizure phenomenologically manifested as a defined movement disorder in 29% of the patients from a consecutive video-EEG documented cohort as per consensus among experts: myoclonus and dystonia (10 and 9 cases, respectively) were the most common movement disorders, followed by chorea (4), stereotypies (3) myoclonus-dystonia (2), and tremor (1). CONCLUSIONS:Movement disorders and focal motor epilepsy share overlapping movement phenomenology.
Authors: Michel Sáenz-Farret; Marina A J Tijssen; Dawn Eliashiv; Robert S Fisher; Kapil Sethi; Alfonso Fasano Journal: CNS Drugs Date: 2022-07-21 Impact factor: 6.497