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Literature DB >> 30361061

The mTOR Independent Function of Tsc1 and FNIPs.

Rebecca A Sager¹, Mark R Woodford¹, Mehdi Mollapour².

Abstract

New roles for Tsc1 and FNIP1/2 as regulators of the molecular chaperone Hsp90 were recently identified, demonstrating a broader cellular impact outside of AMPK-mTOR signaling. In studying the function of these proteins we must take a holistic view of the cell, instead of maintaining our focus on a single pathway.

Entities: Chemical Disease Gene Species

Keywords: Birt-Hogg-Dubé syndrome; Hsp90; co-chaperone; mTOR; tuberous sclerosis complex

Mesh：

Substances：

Year: 2018 PMID： 30361061 PMCID： PMC6324182 DOI： 10.1016/j.tibs.2018.09.018

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

12 in total

1. The Plasticity of the Hsp90 Co-chaperone System.

Authors: Priyanka Sahasrabudhe; Julia Rohrberg; Maximillian M Biebl; Daniel A Rutz; Johannes Buchner
Journal: Mol Cell Date: 2017-09-07 Impact factor: 17.970

2. FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism.

Authors: Jaime Acquaviva; Suqin He; Chaohua Zhang; John-Paul Jimenez; Masazumi Nagai; Jim Sang; Manuel Sequeira; Donald L Smith; Luisa Shin Ogawa; Takayo Inoue; Noriaki Tatsuta; Margaret A Knowles; Richard C Bates; David A Proia
Journal: Mol Cancer Res Date: 2014-04-30 Impact factor: 5.852

3. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs.

Authors: S L Dabora; S Jozwiak; D N Franz; P S Roberts; A Nieto; J Chung; Y S Choy; M P Reeve; E Thiele; J C Egelhoff; J Kasprzyk-Obara; D Domanska-Pakiela; D J Kwiatkowski
Journal: Am J Hum Genet Date: 2000-12-08 Impact factor: 11.025

4. Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies.

Authors: Laura S Schmidt
Journal: Fam Cancer Date: 2013-09 Impact factor: 2.375

Review 5. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.

Authors: Nicole A Neuman; Elizabeth Petri Henske
Journal: EMBO Mol Med Date: 2011-03-16 Impact factor: 12.137

6. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

Authors: Mark R Woodford; Diana M Dunn; Adam R Blanden; Dante Capriotti; David Loiselle; Chrisostomos Prodromou; Barry Panaretou; Philip F Hughes; Aaron Smith; Wendi Ackerman; Timothy A Haystead; Stewart N Loh; Dimitra Bourboulia; Laura S Schmidt; W Marston Linehan; Gennady Bratslavsky; Mehdi Mollapour
Journal: Nat Commun Date: 2016-06-29 Impact factor: 14.919

7. Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy.

Authors: Longze Sha; Xueqin Wang; Jing Li; Xinze Shi; Liwen Wu; Yan Shen; Qi Xu
Journal: J Exp Med Date: 2016-12-27 Impact factor: 14.307

8. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

Authors: Mark R Woodford; Rebecca A Sager; Elijah Marris; Diana M Dunn; Adam R Blanden; Ryan L Murphy; Nicholas Rensing; Oleg Shapiro; Barry Panaretou; Chrisostomos Prodromou; Stewart N Loh; David H Gutmann; Dimitra Bourboulia; Gennady Bratslavsky; Michael Wong; Mehdi Mollapour
Journal: EMBO J Date: 2017-11-10 Impact factor: 11.598

9. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex.

Authors: Maria M Alves; Gwenny M Fuhler; Karla C S Queiroz; Jetse Scholma; Susan Goorden; Jasper Anink; C Arnold Spek; Marianne Hoogeveen-Westerveld; Marco J Bruno; Mark Nellist; Ype Elgersma; Eleonora Aronica; Maikel P Peppelenbosch
Journal: Sci Rep Date: 2015-09-28 Impact factor: 4.379

10. Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dubé: chaperones in pathogenesis.

Authors: Rebecca A Sager; Mark R Woodford; Oleg Shapiro; Mehdi Mollapour; Gennady Bratslavsky
Journal: Oncotarget Date: 2018-04-24

9 in total

1. The multiple facets of the Hsp90 machine.

Authors: Laura J Blair; Olivier Genest; Mehdi Mollapour
Journal: Nat Struct Mol Biol Date: 2019-02 Impact factor: 15.369

2. FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics.

Authors: Yujing Yin; Dengqiu Xu; Yan Mao; Liwei Xiao; Zongchao Sun; Jing Liu; Danxia Zhou; Zhisheng Xu; Lin Liu; Tingting Fu; Chenyun Ding; Qiqi Guo; Wanping Sun; Zheng Zhou; Likun Yang; Yuhuan Jia; Xinyi Chen; Zhenji Gan
Journal: J Exp Med Date: 2022-04-12 Impact factor: 17.579

Review 3. Human Hsp90 cochaperones: perspectives on tissue-specific expression and identification of cochaperones with similar in vivo functions.

Authors: Marissa E Dean; Jill L Johnson
Journal: Cell Stress Chaperones Date: 2020-10-10 Impact factor: 3.667

Review 4. The Role of Heat Shock Protein-90 in the Pathogenesis of Birt-Hogg-Dubé and Tuberous Sclerosis Complex Syndromes.

Authors: Mark R Woodford; Sarah J Backe; Rebecca A Sager; Dimitra Bourboulia; Gennady Bratslavsky; Mehdi Mollapour
Journal: Urol Oncol Date: 2020-04-21 Impact factor: 2.954

5. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.

Authors: Rebecca A Sager; Mark R Woodford; Sarah J Backe; Alan M Makedon; Alexander J Baker-Williams; Bryanna T DiGregorio; David R Loiselle; Timothy A Haystead; Natasha E Zachara; Chrisostomos Prodromou; Dimitra Bourboulia; Laura S Schmidt; W Marston Linehan; Gennady Bratslavsky; Mehdi Mollapour
Journal: Cell Rep Date: 2019-01-29 Impact factor: 9.423

6. Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.

Authors: Mark R Woodford; Michael Hughes; Rebecca A Sager; Sarah J Backe; Alexander J Baker-Williams; Michael S Bratslavsky; Joseph M Jacob; Oleg Shapiro; Michael Wong; Gennady Bratslavsky; Dimitra Bourboulia; Mehdi Mollapour
Journal: Oncotarget Date: 2019-10-08