Literature DB >> 30359109

Identifying Unreported Opioid Deaths Through Toxicology Data and Vital Records Linkage: Case Study in Marion County, Indiana, 2011-2016.

Evan M Lowder1, Bradley R Ray1, Philip Huynh1, Alfarena Ballew1, Dennis P Watson1.   

Abstract

OBJECTIVES: To demonstrate the severity of undercounting opioid-involved deaths in a local jurisdiction with a high proportion of unspecified accidental poisoning deaths.
METHODS: We matched toxicology data to vital records for all accidental poisoning deaths (n = 1238) in Marion County, Indiana, from January 2011 to December 2016. From vital records, we coded cases as opioid involved, specified other substance, or unspecified. We extracted toxicology data on opioid substances for unspecified cases, and we have reported corrected estimates of opioid-involved deaths after accounting for toxicology findings.
RESULTS: Over a 6-year period, 57.7% of accidental overdose deaths were unspecified and 34.2% involved opioids. Toxicology data showed that 86.8% of unspecified cases tested positive for an opioid. Inclusion of toxicology results more than doubled the proportion of opioid-involved deaths, from 34.2% to 86.0%.
CONCLUSIONS: Local jurisdictions may be undercounting opioid-involved overdose deaths to a considerable degree. Toxicology data can improve accuracy in identifying opioid-involved overdose deaths. Public Health Implications. Mandatory toxicology testing and enhanced training for local coroners on standards for death certificate reporting are needed to improve the accuracy of local monitoring of opioid-involved accidental overdose deaths.

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Year:  2018        PMID: 30359109      PMCID: PMC6236744          DOI: 10.2105/AJPH.2018.304683

Source DB:  PubMed          Journal:  Am J Public Health        ISSN: 0090-0036            Impact factor:   9.308


  14 in total

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2.  Obtaining adequate data to determine causes of opioid-related overdose deaths.

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4.  The potential threat of acetyl fentanyl: legal issues, contaminated heroin, and acetyl fentanyl "disguised" as other opioids.

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Journal:  Ann Emerg Med       Date:  2014-08-18       Impact factor: 5.721

5.  Population-Level Analyses Cannot Tell Us Anything About Individual-Level Marijuana-Opioid Substitution.

Authors:  Theodore L Caputi; Kevin A Sabet
Journal:  Am J Public Health       Date:  2018-03       Impact factor: 9.308

6.  Time-Dependent Postmortem Redistribution of Opioids in Blood and Alternative Matrices.

Authors:  Lana Brockbals; Sandra N Staeheli; Dominic Gascho; Lars C Ebert; Thomas Kraemer; Andrea E Steuer
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7.  Corrected US opioid-involved drug poisoning deaths and mortality rates, 1999-2015.

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8.  Morphine to codeine concentration ratio in blood and urine as a marker of illicit heroin use in forensic autopsy samples.

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9.  Complete republication: National Association of Medical Examiners position paper: Recommendations for the investigation, diagnosis, and certification of deaths related to opioid drugs.

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10.  Identifying cases of heroin toxicity where 6-acetylmorphine (6-AM) is not detected by toxicological analyses.

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  6 in total

1.  Unclassified drug overdose deaths in the opioid crisis: emerging patterns of inequity.

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2.  Validating Imputation Procedures to Calculate Corrected Opioid-Involved Overdose Deaths, Marion County, Indiana, 2011-2016.

Authors:  Sumedha Gupta; Alex Cohen; Evan M Lowder; Bradley R Ray
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4.  Using prescribing and toxicology data to determine non-medical prescription drug overdose.

Authors:  Philip Huynh; Grant Victor; Brad Ray
Journal:  Addict Behav Rep       Date:  2020-06-08

5.  Community overdose surveillance: Comparing substances collected from the death scene investigation to toxicology results.

Authors:  Tracy-Lynn E Lockwood; Philip Huynh; Alex Richard; Emily Sightes; Katie Bailey; Bradley Ray; Marya Lieberman
Journal:  Drug Alcohol Depend       Date:  2021-04-24       Impact factor: 4.852

6.  Co-prescription network reveals social dynamics of opioid doctor shopping.

Authors:  Brea L Perry; Kai Cheng Yang; Patrick Kaminski; Meltem Odabas; Jaehyuk Park; Michelle Martel; Carrie B Oser; Patricia R Freeman; Yong-Yeol Ahn; Jeffery Talbert
Journal:  PLoS One       Date:  2019-10-25       Impact factor: 3.240

  6 in total

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