Kate Goldie1, Wouter Peeters2, Mohammed Alghoul3, Kimberly Butterwick4, Gabriela Casabona5, Yates Yen Yu Chao6, Joana Costa7, Joseph Eviatar8, Sabrina Guillen Fabi9, Mary Lupo10, Gerhard Sattler11, Heidi Waldorf12,13, Yana Yutskovskaya14, Paul Lorenc15. 1. European Medical Aesthetics Ltd, London, United Kingdom. 2. Plastic and Reconstructive Surgery, AZ KLINA, Brasschaat, Belgium. 3. Division of Plastic and Reconstructive Surgery, Northwestern Feinberg School of Medicine, Chicago, Illinois. 4. Cosmetic Laser Dermatology, San Diego, California. 5. Scientific Department, Ocean Clinic, Marbella, Spain. 6. CHAO Institute of Aesthetic Medicine, Taipei, Taiwan. 7. Brasília, Brazil. 8. Oculo-facial Plastic Surgery, State University of New York College of Optometry, New York City, New York. 9. Department of Dermatology, University of California, San Diego, California. 10. Department of Dermatology, Tulane Medical School, New Orleans, Louisiana. 11. Rosenparkklinik, Darmstadt, Germany. 12. Waldorf Dermatology Aesthetics, Nanuet, New York. 13. Department of Dermatology, Mount Sinai Hospital, New York, New York. 14. Dermatovenerology and Cosmetology Department, Pacific State Medical University of Health, Moscow, Russia. 15. Department of Plastic Surgery, Lenox Hill Hospital, New York, New York.
Abstract
BACKGROUND: Calcium hydroxylapatite (CaHA) is approved to correct moderate-to-severe wrinkles and folds and soft-tissue volume loss in the face and hands. More recently, subdermal injection using diluted CaHA has been used to improve skin laxity. OBJECTIVE: To review evidence for the safe and effective use of diluted CaHA in the face and body and provide best practice recommendations. METHODS: A global panel of expert aesthetic physicians convened to develop consensus-based guidelines for treating laxity and superficial wrinkles using diluted (ratio of 1:1) and hyperdiluted (≥1:2) CaHA. RESULTS: Diluted and hyperdiluted CaHA stimulates targeted neocollagenesis in the injection area to improve laxity and skin quality in the mid- and lower face, neck, décolletage, upper arms, abdomen, upper legs, and buttocks. Treatment can be used as an adjunct to volume augmentation or combined with additional modalities for optimal results. Adverse events are related to the injection and include bruising, swelling, mild pain, and induration. In thinner and darker skin, too-superficial injections of less diluted CaHA can lead to more adverse events. CONCLUSION: This report provides preliminary guidelines for the novel off-label use of CaHA for biostimulation in the face and body. Further trials will provide additional clarity regarding treatment paradigms for optimal outcomes.
BACKGROUND:Calcium hydroxylapatite (CaHA) is approved to correct moderate-to-severe wrinkles and folds and soft-tissue volume loss in the face and hands. More recently, subdermal injection using diluted CaHA has been used to improve skin laxity. OBJECTIVE: To review evidence for the safe and effective use of diluted CaHA in the face and body and provide best practice recommendations. METHODS: A global panel of expert aesthetic physicians convened to develop consensus-based guidelines for treating laxity and superficial wrinkles using diluted (ratio of 1:1) and hyperdiluted (≥1:2) CaHA. RESULTS: Diluted and hyperdiluted CaHA stimulates targeted neocollagenesis in the injection area to improve laxity and skin quality in the mid- and lower face, neck, décolletage, upper arms, abdomen, upper legs, and buttocks. Treatment can be used as an adjunct to volume augmentation or combined with additional modalities for optimal results. Adverse events are related to the injection and include bruising, swelling, mild pain, and induration. In thinner and darker skin, too-superficial injections of less diluted CaHA can lead to more adverse events. CONCLUSION: This report provides preliminary guidelines for the novel off-label use of CaHA for biostimulation in the face and body. Further trials will provide additional clarity regarding treatment paradigms for optimal outcomes.
Authors: Je-Young Park; Jeng-Feng Chen; Hosung Choi; Wilson W S Ho; Ni Nyoman Indra Lesthari; Joyce Teng Ee Lim; Ting Song Lim; Stephen Lowe; Beverly Ong-Amoranto; Vasanop Vachiramon; Rungsima Wanitphakdeedecha; Martina Kerscher Journal: J Clin Aesthet Dermatol Date: 2022-06
Authors: Jani van Loghem; David Funt; Tatjana Pavicic; Kate Goldie; Yana Yutskovskaya; Sabrina Fabi; Pieter Siebenga; Job Thuis; Joseph Hkeik; Jonathan Kadouch; Welf Prager; Nabila Azib; Gabriela Casabona; Steve Dayan; Shino Bay Aguilera; Philippe Snozzi; Peerooz Saeed Journal: J Cosmet Dermatol Date: 2020-03-17 Impact factor: 2.696
Authors: Z Paul Lorenc; Jeanette M Black; Jessie S Cheung; Annie Chiu; Roberta Del Campo; Alan James Durkin; Miles Graivier; Jeremy B Green; Gideon P Kwok; Keith Marcus; Charalambos Babis Rammos; William Philip Werschler Journal: Aesthet Surg J Date: 2022-01-01 Impact factor: 4.283