Chengzhi Zhan1, Tao Wang, Hua You, Cheng Si. 1. Department of Pathology, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.
Abstract
PURPOSE: To explore the roles of micro RNAs (miRs)-125b and SOX30 in malignant lymphomas. METHODS: The correction of miR-125b targeting SOX30 was examined by the luciferase reporter assay. The expression levels of miR-125b and SOX30 were tested by in situ hybridization and immunohistochemistry. RESULTS: miR-125b was able to bind to the 3'UTR of SOX30 gene and was negatively associated with SOX30. As compared with the reactive hyperplasia lymphatic samples, the higher (miR-125b) and lower (SOX30) rate was expressed positively in the malignant lymphomas, which was related to the stage and grade of malignancy. CONCLUSIONS: miR-125b can regulate SOX30 by binding to its 3'UTR. miR-125b and SOX30 act as diagnostic and therapeutic markers for malignant lymphoma.
PURPOSE: To explore the roles of micro RNAs (miRs)-125b and SOX30 in malignant lymphomas. METHODS: The correction of miR-125b targeting SOX30 was examined by the luciferase reporter assay. The expression levels of miR-125b and SOX30 were tested by in situ hybridization and immunohistochemistry. RESULTS:miR-125b was able to bind to the 3'UTR of SOX30 gene and was negatively associated with SOX30. As compared with the reactive hyperplasia lymphatic samples, the higher (miR-125b) and lower (SOX30) rate was expressed positively in the malignant lymphomas, which was related to the stage and grade of malignancy. CONCLUSIONS:miR-125b can regulate SOX30 by binding to its 3'UTR. miR-125b and SOX30 act as diagnostic and therapeutic markers for malignant lymphoma.