Maxim Verboven1, Lisa Van Ryckeghem1,2, Jamal Belkhouribchia1,2, Paul Dendale1,3, Bert O Eijnde1, Dominique Hansen4,5,6, Virginie Bito1. 1. BIOMED-Biomedical Research Centre, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan building C, 3590, Diepenbeek, Belgium. 2. REVAL-Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Hasselt University, Agoralaan building A, 3590, Diepenbeek, Belgium. 3. Heart Centre Hasselt, Jessa Hospital, Hasselt, Belgium. 4. BIOMED-Biomedical Research Centre, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan building C, 3590, Diepenbeek, Belgium. Dominique.hansen@uhasselt.be. 5. REVAL-Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Hasselt University, Agoralaan building A, 3590, Diepenbeek, Belgium. Dominique.hansen@uhasselt.be. 6. Heart Centre Hasselt, Jessa Hospital, Hasselt, Belgium. Dominique.hansen@uhasselt.be.
Abstract
BACKGROUND: The effect of exercise on cardiac function/structure in type 2 diabetes mellitus (T2DM) with or without diabetic cardiomyopathy (DCM) is not yet completely understood. To date, results of studies have been controversial with variable outcomes due to the variety of exercise modalities. OBJECTIVES: The aim of the present review was to examine the impact of exercise intervention, and different types of exercise, on cardiac function and structure in T2DM through a systematic literature review, combining both pre-clinical and clinical studies. METHODS: A systematic literature search was performed on PubMed, Web of Science, and PEDro to identify studies up to 2 April 2018. Articles were included when well-defined exercise protocols were provided, and cardiac function in T2DM patients or validated animal models was examined. RESULTS: In diabetic animals, improvements in both diastolic and systolic function through exercise therapy were mainly attributed to reduced collagen deposition. In T2DM patients, improvements were observed in diastolic function, but not consistently in systolic function, after endurance (and combined resistance) exercise training. Different exercise intervention modalities and exercise types seemed equally effective in improving cardiac structure and function. CONCLUSION: Exercise training elicits significant improvements in diastolic function and beneficial remodeling in T2DM and DCM animal models, but not necessarily improvements in systolic function and left ventricular structure, regardless of exercise type. Therefore, exercise intervention should be a cornerstone in the treatment of T2DM patients not only to improve glycemic control but also to specifically enhance cardiac function.
BACKGROUND: The effect of exercise on cardiac function/structure in type 2 diabetes mellitus (T2DM) with or without diabetic cardiomyopathy (DCM) is not yet completely understood. To date, results of studies have been controversial with variable outcomes due to the variety of exercise modalities. OBJECTIVES: The aim of the present review was to examine the impact of exercise intervention, and different types of exercise, on cardiac function and structure in T2DM through a systematic literature review, combining both pre-clinical and clinical studies. METHODS: A systematic literature search was performed on PubMed, Web of Science, and PEDro to identify studies up to 2 April 2018. Articles were included when well-defined exercise protocols were provided, and cardiac function in T2DM patients or validated animal models was examined. RESULTS: In diabetic animals, improvements in both diastolic and systolic function through exercise therapy were mainly attributed to reduced collagen deposition. In T2DM patients, improvements were observed in diastolic function, but not consistently in systolic function, after endurance (and combined resistance) exercise training. Different exercise intervention modalities and exercise types seemed equally effective in improving cardiac structure and function. CONCLUSION: Exercise training elicits significant improvements in diastolic function and beneficial remodeling in T2DM and DCM animal models, but not necessarily improvements in systolic function and left ventricular structure, regardless of exercise type. Therefore, exercise intervention should be a cornerstone in the treatment of T2DM patients not only to improve glycemic control but also to specifically enhance cardiac function.
Authors: Waleed Alhumaid; Stephanie D Small; Amy A Kirkham; Harald Becher; Edith Pituskin; Carla M Prado; Richard B Thompson; Mark J Haykowsky; D Ian Paterson Journal: Front Cardiovasc Med Date: 2022-02-21
Authors: Kaberi Dasgupta; Thomas Yates; Normand Boulé; Joseph Henson; Stéphanie Chevalier; Emma Redman; Deborah Chan; Matthew McCarthy; Julia Champagne; Frank Arsenyadis; Jordan Rees; Deborah Da Costa; Edward Gregg; Roseanne Yeung; Michelle Hadjiconstantinou; Abhishek Dattani; Matthias G Friedrich; Kamlesh Khunti; Elham Rahme; Isabel Fortier; Carla M Prado; Mark Sherman; Richard B Thompson; Melanie J Davies; Gerry P McCann Journal: BMJ Open Date: 2022-09-21 Impact factor: 3.006