S Amal Hussnain1,2,3,4, Rosa Dolz-Marco1,2,5, Joshua L Dunaief6, Christine A Curcio7, K Bailey Freund1,2,3,4. 1. Vitreous Retina Macula Consultants of New York, New York, New York. 2. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York. 3. Department of Ophthalmology, Edward S Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York. 4. Department of Ophthalmology, New York University School of Medicine, New York, New York. 5. Unit of Macula, Oftalvist Clinic, Valencia, Spain. 6. F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 7. Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama.
Abstract
PURPOSE: To describe patterns of hypoautofluorescence in eyes with neovascular age-related macular degeneration occurring after subretinal hemorrhage. METHODS: This was a retrospective descriptive analysis of neovascular age-related macular degeneration eyes presenting with subretinal hemorrhage over the last 5 years that underwent serial multimodal imaging. A review of color fundus photographs, fundus autofluorescence, near-infrared reflectance, and optical coherence tomography was performed at baseline and all available follow-up visits to document the course and evolution of subretinal hemorrhage in these eyes. RESULTS: Eleven eyes of 10 patients (9 female, 1 male; mean age: 84.1 years, range: 72-99 years) with a mean follow-up of 19.8 months (range: 3-68 months) were included. Color fundus photographs showed subretinal hemorrhage that resolved over a mean of 5.5 months. During and after hemorrhage resolution, all eyes showed hypoautofluorescence, which appeared distinct from that due to retinal pigment epithelium loss. Discrete multifocal punctate hyperpigmented lesions were observed in 90% of eyes and were markedly hypoautofluorescent, producing a speckled pattern on fundus autofluorescence. CONCLUSION: Areas of hypoautofluorescence in the absence of retinal pigment epithelium atrophy, often with a speckled pattern, delineate areas of prior subretinal hemorrhage long after its resolution in patients with neovascular age-related macular degeneration. Potential mechanisms for the development of this pattern are proposed.
PURPOSE: To describe patterns of hypoautofluorescence in eyes with neovascular age-related macular degeneration occurring after subretinal hemorrhage. METHODS: This was a retrospective descriptive analysis of neovascular age-related macular degeneration eyes presenting with subretinal hemorrhage over the last 5 years that underwent serial multimodal imaging. A review of color fundus photographs, fundus autofluorescence, near-infrared reflectance, and optical coherence tomography was performed at baseline and all available follow-up visits to document the course and evolution of subretinal hemorrhage in these eyes. RESULTS: Eleven eyes of 10 patients (9 female, 1 male; mean age: 84.1 years, range: 72-99 years) with a mean follow-up of 19.8 months (range: 3-68 months) were included. Color fundus photographs showed subretinal hemorrhage that resolved over a mean of 5.5 months. During and after hemorrhage resolution, all eyes showed hypoautofluorescence, which appeared distinct from that due to retinal pigment epithelium loss. Discrete multifocal punctate hyperpigmented lesions were observed in 90% of eyes and were markedly hypoautofluorescent, producing a speckled pattern on fundus autofluorescence. CONCLUSION: Areas of hypoautofluorescence in the absence of retinal pigment epithelium atrophy, often with a speckled pattern, delineate areas of prior subretinal hemorrhage long after its resolution in patients with neovascular age-related macular degeneration. Potential mechanisms for the development of this pattern are proposed.
Authors: Robert B Bhisitkul; Bryan J Winn; On-Tat Lee; Joshua Wong; Daniel de Souza Pereira; Travis C Porco; Xining He; Paul Hahn; Joshua L Dunaief Journal: Invest Ophthalmol Vis Sci Date: 2008-04-17 Impact factor: 4.799
Authors: Majda Hadziahmetovic; Tzvete Dentchev; Ying Song; Nadine Haddad; Xining He; Paul Hahn; Domenico Pratico; Rong Wen; Z Leah Harris; John D Lambris; John Beard; Joshua L Dunaief Journal: Invest Ophthalmol Vis Sci Date: 2008-03-07 Impact factor: 4.799
Authors: Leon von der Emde; Maximilian Pfau; Chantal Dysli; Sarah Thiele; Philipp T Möller; Moritz Lindner; Matthias Schmid; Monika Fleckenstein; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Sci Rep Date: 2019-07-31 Impact factor: 4.379