Literature DB >> 30355081

Epigenetic Modifications in Cardiovascular Aging and Diseases.

Weiqi Zhang1,2,3,4, Moshi Song5,3,4, Jing Qu6,3,4, Guang-Hui Liu1,2,3,4.   

Abstract

Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.

Entities:  

Keywords:  aging; disease; epigenomics; genomics; histones

Mesh：

Substances：

Year:  2018        PMID： 30355081     DOI： 10.1161/CIRCRESAHA.118.312497

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  60 in total

Review 1.  Targeting Age-Related Pathways in Heart Failure.

Authors:  Haobo Li; Margaret H Hastings; James Rhee; Lena E Trager; Jason D Roh; Anthony Rosenzweig
Journal:  Circ Res       Date:  2020-02-13       Impact factor: 17.367

2.  Clinical epigenomics for cardiovascular disease: Diagnostics and therapies.

Authors:  Matthew A Fischer; Thomas M Vondriska
Journal:  J Mol Cell Cardiol       Date:  2021-02-06       Impact factor: 5.000

3.  Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.

Authors:  Gaurav Ahuja; Deniz Bartsch; Wenjie Yao; Simon Geissen; Stefan Frank; Aitor Aguirre; Nicole Russ; Jan-Erik Messling; Joanna Dodzian; Kim A Lagerborg; Natalia Emilse Vargas; Joscha Sergej Muck; Susanne Brodesser; Stephan Baldus; Agapios Sachinidis; Juergen Hescheler; Christoph Dieterich; Aleksandra Trifunovic; Argyris Papantonis; Michael Petrascheck; Anna Klinke; Mohit Jain; Dario Riccardo Valenzano; Leo Kurian
Journal:  EMBO Rep       Date:  2019-03-18       Impact factor: 8.807

Review 4.  Epigenetic regulation of anterior segment diseases and potential therapeutics.

Authors:  Eric Chen; Kelley Bohm; Mark Rosenblatt; Kai Kang
Journal:  Ocul Surf       Date:  2020-04-25       Impact factor: 5.033

Review 5.  Metabolic choreography of gene expression: nutrient transactions with the epigenome.

Authors:  Babukrishna Maniyadath; U S Sandra; Ullas Kolthur-Seetharam
Journal:  J Biosci       Date:  2020       Impact factor: 1.826

Review 6.  Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer.

Authors:  Andrew W Caliri; Stella Tommasi; Ahmad Besaratinia
Journal:  Mutat Res Rev Mutat Res       Date:  2021-01-11       Impact factor: 5.657

Review 7.  N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases.

Authors:  Ye-Shi Chen; Xin-Ping Ouyang; Xiao-Hua Yu; Petr Novák; Le Zhou; Ping-Ping He; Kai Yin
Journal:  J Cardiovasc Transl Res       Date:  2021-02-25       Impact factor: 4.132

Review 8.  Senescence mechanisms and targets in the heart.

Authors:  Maggie S Chen; Richard T Lee; Jessica C Garbern
Journal:  Cardiovasc Res       Date:  2022-03-25       Impact factor: 10.787

9.  Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms.

Authors:  Gita A Pathak; Frank R Wendt; Antonella De Lillo; Yaira Z Nunez; Aranyak Goswami; Flavio De Angelis; Maria Fuciarelli; Henry R Kranzler; Joel Gelernter; Renato Polimanti
Journal:  Circ Genom Precis Med       Date:  2021-01-11

10.  The Epigenome in Atherosclerosis.

Authors:  Sarah Costantino; Francesco Paneni
Journal:  Handb Exp Pharmacol       Date:  2022
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