Literature DB >> 30354939

Spermidine reduces cancer-related mortality in humans.

Federico Pietrocola1,2, Francesca Castoldi2,3,4,5,6,7,8, Oliver Kepp2,3,4,5,6,7,8, Didac Carmona-Gutierrez9,10, Frank Madeo9,10, Guido Kroemer2,3,4,5,6,7,8,11,12.   

Abstract

A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects. Abbreviations: ACLY, ATP citrate lyase; ATG, autophagy-related gene; CoA, coenzyme A; NSCLC, non-small cell lung cancer.

Entities:  

Keywords:  Aspirin; Autophagy; aging; immunosurveillance; inflammation

Mesh：

Substances：

Year:  2018        PMID： 30354939      PMCID： PMC6333461          DOI： 10.1080/15548627.2018.1539592

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  52 in total

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Journal:  Am J Clin Nutr       Date:  2018-08-01       Impact factor: 7.045
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10.  Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice.

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