| Literature DB >> 3035440 |
Abstract
Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded that GABAergic nerve terminals in rat hippocampus possess adrenoceptors of the alpha 2-subtype whose activation causes enhancement of GABA release.Entities:
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Year: 1987 PMID： 3035440 DOI： 10.1016/0304-3940(87)90430-7
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046