James J Malone1, Minoo Bassami2, Sarah C Waldron3, Iain T Campbell3, Andrew Hulton4, Dominic Doran5, Don P MacLaren5. 1. School of Health Sciences, Liverpool Hope University, Taggart Avenue, Liverpool, L16 9JD, UK. malonej2@hope.ac.uk. 2. Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran. 3. Department of Anaesthesia, University Hospital of South Manchester, Manchester, UK. 4. School of Biosciences and Medicine, University of Surrey, Guildford, UK. 5. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Abstract
PURPOSE: The purpose of the present study was to investigate the age-related carbohydrate oxidation and glucose utilisation rate response during exercise at the same relative intensity under hyperglycaemia in aged and young males. METHODS: 16 endurance-trained aged (n = 8; 69.1 ± 5.2 year) and young (n = 8; 22.4 ± 2.9 year) males were studied during 40 min of cycling exercise (60% [Formula: see text]) under both hyperglycaemic and euglycaemic (control) conditions. Venous blood samples were collected at baseline, post-infusion, mid- and post-exercise. Carbohydrate and fat oxidation rates were determined at both 15 and 35 min during exercise, and glucose utilisation rates were calculated. RESULTS: The aged group displayed significantly lower rates of carbohydrate oxidation during exercise during maintained hyperglycemia (15 min = 2.3 ± 0.4 vs. 1.6 ± 0.5 g min-1; 35 min = 2.3 ± 0.5 vs. 1.5 ± 0.5 g min-1) and control (15 min = 2.2 ± 0.4 vs. 1.6 ± 0.7 g min-1; 35 min = 1.9 ± 0.7 vs. 1.3 ± 0.7 g min-1) conditions (P = 0.01). The rate of glucose utilisation during exercise was also significantly reduced (85.76 ± 23.95 vs. 56.67 ± 15.09 μM kg-1 min-1). There were no differences between age groups for anthropometric measures, fat oxidation, insulin, glucose, NEFA, glycerol and lactate (P > 0.05) although hyperglycemia resulted in elevated glucose and insulin, and attenuated fat metabolite levels. CONCLUSION: Our findings highlight that ageing results in a reduction in carbohydrate oxidation and utilisation rates during exercise at the same relative exercise intensity.
PURPOSE: The purpose of the present study was to investigate the age-related carbohydrate oxidation and glucose utilisation rate response during exercise at the same relative intensity under hyperglycaemia in aged and young males. METHODS: 16 endurance-trained aged (n = 8; 69.1 ± 5.2 year) and young (n = 8; 22.4 ± 2.9 year) males were studied during 40 min of cycling exercise (60% [Formula: see text]) under both hyperglycaemic and euglycaemic (control) conditions. Venous blood samples were collected at baseline, post-infusion, mid- and post-exercise. Carbohydrate and fat oxidation rates were determined at both 15 and 35 min during exercise, and glucose utilisation rates were calculated. RESULTS: The aged group displayed significantly lower rates of carbohydrate oxidation during exercise during maintained hyperglycemia (15 min = 2.3 ± 0.4 vs. 1.6 ± 0.5 g min-1; 35 min = 2.3 ± 0.5 vs. 1.5 ± 0.5 g min-1) and control (15 min = 2.2 ± 0.4 vs. 1.6 ± 0.7 g min-1; 35 min = 1.9 ± 0.7 vs. 1.3 ± 0.7 g min-1) conditions (P = 0.01). The rate of glucose utilisation during exercise was also significantly reduced (85.76 ± 23.95 vs. 56.67 ± 15.09 μM kg-1 min-1). There were no differences between age groups for anthropometric measures, fat oxidation, insulin, glucose, NEFA, glycerol and lactate (P > 0.05) although hyperglycemia resulted in elevated glucose and insulin, and attenuated fat metabolite levels. CONCLUSION: Our findings highlight that ageing results in a reduction in carbohydrate oxidation and utilisation rates during exercise at the same relative exercise intensity.
Authors: Ellen M Evans; Susan B Racette; Linda R Peterson; Dennis T Villareal; Jeffrey S Greiwe; John O Holloszy Journal: J Appl Physiol (1985) Date: 2005-01
Authors: Kevin R Short; Janet L Vittone; Maureen L Bigelow; David N Proctor; Robert A Rizza; Jill M Coenen-Schimke; K Sreekumaran Nair Journal: Diabetes Date: 2003-08 Impact factor: 9.461
Authors: Hamid Mohebbi; Iain T Campbell; Marie A Keegan; James J Malone; Andrew T Hulton; Don P M MacLaren Journal: Eur J Appl Physiol Date: 2019-11-09 Impact factor: 3.078