| Literature DB >> 30353296 |
Rosa M Agra-Bermejo1,2,3, Rocio Gonzalez-Ferreiro1,2,3, J Nicolos Lopez-Canoa1,2,3, Alfonso Varela-Roman1,2,3, Ines Gomez-Otero1,2,3, Sonia Eiras4,5,6, José R González-Juanatey1,2,3.
Abstract
A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. The mean follow-up was 256 ± 143 days. Leptin and adiponectin levels were similar among weight groups. However, omentin levels were higher in those patients who had gained weight (16 ± 5 ng/mL) than in those who had lost weight (12 ± 4 ng/mL) or showed no weight change (11 ± 5 ng/mL; p < 0.002). Omentin levels were the best independent predictors for patients with weight gain, who had less mortality and hospital readmission during the follow-up. The association between omentin levels and weight gain might explain part of the obesity paradox in HF.Entities:
Keywords: Acute heart failure; Adipokines; Body weight changes
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Year: 2018 PMID： 30353296 DOI： 10.1007/s12265-018-9840-y
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132