F Chollet1,2, J Rigal3,4, P Marque4,5, M Barbieux-Guillot3,4, N Raposo3,4, V Fabry3, J F Albucher3,4, J Pariente3,4, I Loubinoux4. 1. Neurology Department, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. fchperso@gmail.com. 2. Toulouse Neuro-Imaging, Inserm, UPS, Université de Toulouse, Toulouse, France. fchperso@gmail.com. 3. Neurology Department, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. 4. Toulouse Neuro-Imaging, Inserm, UPS, Université de Toulouse, Toulouse, France. 5. Rehabilitation Department, Hôpital de Rangueil, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Abstract
PURPOSE OF REVIEW: The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects. RECENT FINDINGS: Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.
PURPOSE OF REVIEW: The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects. RECENT FINDINGS: Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of strokepatient meta-analysis, and confirmation of favourable safety conditions in post-strokepatients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.
Authors: S C Cramer; G Nelles; R R Benson; J D Kaplan; R A Parker; K K Kwong; D N Kennedy; S P Finklestein; B R Rosen Journal: Stroke Date: 1997-12 Impact factor: 7.914
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