Cecilia Toppe1,2, Anna Möllsten3, Ingeborg Waernbaum4, Staffan Schön5, Soffia Gudbjörnsdottir6, Mona Landin-Olsson7, Gisela Dahlquist. 1. Paediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden cecilia.toppe@rjl.se. 2. Department of Internal Medicine, Ryhov County Hospital, Jönköping, Sweden. 3. Paediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden. 4. Department of Statistics, Umeå University, Umeå, Sweden. 5. Swedish Renal Registry, Jönköping, Sweden. 6. Swedish National Diabetes Register, Gothenburg, Sweden. 7. Diabetes Incidence Study in Sweden, Department of Clinical Sciences, Lund University, Lund, Sweden.
Abstract
OBJECTIVE: Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS: In this study, patients with duration of type 1 diabetes >14 years and age at onset of diabetes 0-34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS: We found that the cumulative incidence of ESRD in Sweden was low after up to 38 years of diabetes duration (5.6%). The incidence of ESRD was lower in patients with type 1 diabetes onset in 1991-2001 compared with onset in 1977-1984 and 1985-1990, independent of diabetes duration. CONCLUSIONS: The risk of developing ESRD in Sweden in this population is still low and also seems to decrease with time.
OBJECTIVE:Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS: In this study, patients with duration of type 1 diabetes >14 years and age at onset of diabetes 0-34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS: We found that the cumulative incidence of ESRD in Sweden was low after up to 38 years of diabetes duration (5.6%). The incidence of ESRD was lower in patients with type 1 diabetes onset in 1991-2001 compared with onset in 1977-1984 and 1985-1990, independent of diabetes duration. CONCLUSIONS: The risk of developing ESRD in Sweden in this population is still low and also seems to decrease with time.
Authors: Thomas Ebert; Sven-Christian Pawelzik; Anna Witasp; Samsul Arefin; Sam Hobson; Karolina Kublickiene; Paul G Shiels; Magnus Bäck; Peter Stenvinkel Journal: Toxins (Basel) Date: 2020-04-04 Impact factor: 4.546