Literature DB >> 3035283

The cholecalciferol sulphate system in mammals.

M Axelson.   

Abstract

7-Dehydrocholesterol sulphate has been identified in human and rat skin. The compound was isolated by anion exchange chromatography and following hydrolysis it was characterized by high-performance liquid chromatography and gas chromatography-mass spectrometry. Experiments with rats showed that 7-dehydrocholesterol sulphate can serve as a precursor of cholecalciferol sulphate and 25-hydroxy-cholecalciferol 3-sulphate, the latter compound being present in significant amounts in human blood. The sulphated sterols identified represent a previously unknown secosteroid system in mammals.

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Year:  1987        PMID： 3035283     DOI： 10.1016/0022-4731(87)90103-8

Source DB:  PubMed          Journal:  J Steroid Biochem        ISSN： 0022-4731            Impact factor:   4.292


  2 in total

1.  Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes.

Authors:  Elizabeth A Rondini; Asmita Pant; Thomas A Kocarek
Journal:  J Pharmacol Exp Ther       Date:  2015-10-01       Impact factor: 4.030

2.  Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Authors:  Timothy Wong; Zhican Wang; Brian D Chapron; Mizuki Suzuki; Katrina G Claw; Chunying Gao; Robert S Foti; Bhagwat Prasad; Alenka Chapron; Justina Calamia; Amarjit Chaudhry; Erin G Schuetz; Ronald L Horst; Qingcheng Mao; Ian H de Boer; Timothy A Thornton; Kenneth E Thummel
Journal:  Drug Metab Dispos       Date:  2018-01-17       Impact factor: 3.922
  2 in total

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