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Literature DB >> 30352704

Safe CRISPR: Challenges and Possible Solutions.

Michael Pineda¹, Ashley Lear¹, James P Collins², Samira Kiani³.

Abstract

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

Entities: Chemical

Keywords: CRISPR; biosafety; gene drives; gene therapies

Mesh：

Year: 2018 PMID： 30352704 DOI： 10.1016/j.tibtech.2018.09.010

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

Keyword Cloud
Cited

13 in total

1. An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy.

Authors: Gang Niu; Zhuang Jin; Chong Zhang; Dan He; Xueqin Gao; Chenming Zou; Wei Zhang; Jiahui Ding; Bhudev C Das; Konstantin Severinov; Inga Isabel Hitzeroth; Priya Ranjan Debata; Xin Ma; Xun Tian; Qinglei Gao; Jun Wu; Zeshan You; Rui Tian; Zifeng Cui; Weiwen Fan; Weiling Xie; Zhaoyue Huang; Chen Cao; Wei Xu; Hongxian Xie; Hongyan Xu; Xiongzhi Tang; Yan Wang; Zhiying Yu; Hui Han; Songwei Tan; Shuqin Chen; Zheng Hu
Journal: EBioMedicine Date: 2020-07-22 Impact factor: 8.143

2. Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.

Authors: Han-Xiang Deng; Hong Zhai; Yong Shi; Guoxiang Liu; Jessica Lowry; Bin Liu; Éanna B Ryan; Jianhua Yan; Yi Yang; Nigel Zhang; Zhihua Yang; Erdong Liu; Yongchao C Ma; Teepu Siddique
Journal: Commun Biol Date: 2021-03-25

Review 3. A review of COVID-19: Treatment strategies and CRISPR/Cas9 gene editing technology approaches to the coronavirus disease.

Authors: Muhammad Farhat Ullah; Yasir Ali; Muhammad Ramzan Khan; Inam Ullah Khan; Bing Yan; M Ijaz Khan; M Y Malik
Journal: Saudi J Biol Sci Date: 2021-10-13 Impact factor: 4.219

4. Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing.

Authors: Ziwen Zheng; Guo Li; Chong Cui; Fang Wang; Xiaohan Wang; Zhijiao Xu; Huiping Guo; Yuxin Chen; Honghai Tang; Daqi Wang; Mingqian Huang; Zheng-Yi Chen; Xingxu Huang; Huawei Li; Geng-Lin Li; Xiaoxiang Hu; Yilai Shu
Journal: Signal Transduct Target Ther Date: 2022-03-14

5. Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.

Authors: Jonathan O'Keeffe Ahern; Irene Lara-Sáez; Dezhong Zhou; Rodolfo Murillas; Jose Bonafont; Ángeles Mencía; Marta García; Darío Manzanares; Jennifer Lynch; Ruth Foley; Qian Xu; A Sigen; Fernando Larcher; Wenxin Wang
Journal: Gene Ther Date: 2021-08-06 Impact factor: 4.184

Review 6. Novel plant breeding techniques to advance nitrogen use efficiency in rice: A review.

Authors: Sajid Fiaz; Xiukang Wang; Sher Aslam Khan; Sunny Ahmar; Mehmood Ali Noor; Aamir Riaz; Kazim Ali; Farhat Abbas; Freddy Mora-Poblete; Carlos R Figueroa; Badr Alharthi
Journal: GM Crops Food Date: 2021-05-25 Impact factor: 3.118

Review 7. Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia.

Authors: Fengxuan Han; Jiayuan Wang; Luguang Ding; Yuanbin Hu; Wenquan Li; Zhangqin Yuan; Qianping Guo; Caihong Zhu; Li Yu; Huan Wang; Zhongliang Zhao; Luanluan Jia; Jiaying Li; Yingkang Yu; Weidong Zhang; Genglei Chu; Song Chen; Bin Li
Journal: Front Bioeng Biotechnol Date: 2020-03-24