Petronilla Battista1,2,3, Eleonora Catricalà4, Marco Piccininni1,2, Massimiliano Copetti5, Valentina Esposito6,7, Cristina Polito3, Antonio Miozzo8, Elena Gobbi7,9, Sofia Cuoco10, Veronica Boschi4, Marina Picillo10, Sandro Sorbi3,11, Paolo Barone10, Sandro Iannaccone6, Peter Garrard12, Giancarlo Logroscino1,2, Stefano F Cappa13,14. 1. Department of Basic Medical Sciences, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy. 2. Neurodegenerative Disease Unit, Department of Clinical Research in Neurology, University of Bari Aldo Moro, "Pia Fondazione Cardinale G. Panico", Tricase, Italy. 3. NEUROFARBA - Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università di Firenze, Florence, Italy. 4. Center for Neurocognition and Theoretical Syntax, Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy. 5. Biostatistics Unit, IRCCS-Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. 6. Department of Specialistic Rehabilitation of Neurological, Cognitive, and Motor Disorders, IRCCS San Raffaele Hospital and Vita-Salute University, Milan, Italy. 7. Università Vita-Salute San Raffaele, Milan, Italy. 8. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. 9. IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. 10. Dipartimento di Medicina e Chirurgia, Università di Salerno, Salerno, Italy. 11. IRCCS Don Gnocchi Firenze, Florence, Italy. 12. Neuroscience Research Center, St George's University of London, London, United Kingdom. 13. Center for Neurocognition and Theoretical Syntax, Scuola Universitaria Superiore IUSS Pavia, Pavia, Italystefano.cappa@iusspavia.it. 14. IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italystefano.cappa@iusspavia.it.
Abstract
BACKGROUND: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. METHODS: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). RESULTS: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.978 for PPA versus HC and of 0.786 for PPA versus MD. A cutoff ≥3 gave a sensitivity of 0.933% and a specificity of 0.946% for discriminating PPA versus HC, whereas a cutoff ≥5 gave a sensitivity of 0.767% and a specificity of 0.667% for discriminating PPA versus MD. CONCLUSION: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA.
BACKGROUND: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. METHODS: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). RESULTS: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.978 for PPA versus HC and of 0.786 for PPA versus MD. A cutoff ≥3 gave a sensitivity of 0.933% and a specificity of 0.946% for discriminating PPA versus HC, whereas a cutoff ≥5 gave a sensitivity of 0.767% and a specificity of 0.667% for discriminating PPA versus MD. CONCLUSION: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA.