Søs Dragsbæk Larsen1, Christine Dalgård2, Mathilde Egelund Christensen3, Sine Lykkedegn4, Louise Bjørkholt Andersen5, Marianne Andersen6, Dorte Glintborg7, Henrik Thybo Christesen8. 1. S Larsen, Clinical Research, Syddansk Universitet Det Sundhedsvidenskabelige Fakultet, Odense, 5230, Denmark. 2. C Dalgård, Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark. 3. M Christensen, Clinical Research, Syddansk Universitet Det Sundhedsvidenskabelige Fakultet, Odense, Denmark. 4. S Lykkedegn, Hans Christian Andersen Children's Hospital, Odense Universitetshospital, Odense, Denmark. 5. L Andersen, Department of Obstetrics and Gynecology, Herlev Hospital, Herlev, Denmark. 6. M Andersen, Endocrinology, Odense Universitetshospital, Odense, Denmark. 7. D Glintborg, Endocrinology, Odense University Hospital, Odense , DK-5000, Denmark. 8. H Christesen, Hans Christian Andersen Children's Hospital, Odense Universitetshospital, Odense, Denmark.
Abstract
BACKGROUND: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. OBJECTIVE: To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to three years of age. DESIGN: Prospective, population-based cohort study. METHODS: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls), or three years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. RESULTS: In 3-y-old girls, SBP decreased with -0.7mmHg (95%CI -1.1;-0.3, p=0.001) and DBP with -0.4mmHg (95%CI -0.7;-0.1, p=0.016) for every 10nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile was reduced by 30% for every 10nmol/L increase in cord s-25OHD (p=0.004); and by 64% for cord s-25OHD above the median 45.1nmol/L (p=0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at three years. No consistent associations were observed between s-25OHD and BP in boys. CONCLUSION: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.
BACKGROUND: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. OBJECTIVE: To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to three years of age. DESIGN: Prospective, population-based cohort study. METHODS: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls), or three years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. RESULTS: In 3-y-old girls, SBP decreased with -0.7mmHg (95%CI -1.1;-0.3, p=0.001) and DBP with -0.4mmHg (95%CI -0.7;-0.1, p=0.016) for every 10nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile was reduced by 30% for every 10nmol/L increase in cord s-25OHD (p=0.004); and by 64% for cord s-25OHD above the median 45.1nmol/L (p=0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at three years. No consistent associations were observed between s-25OHD and BP in boys. CONCLUSION: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.
Authors: Per Tornhammar; Peter Ueda; Martin Hult; Henry Simila; Darryl Eyles; Mikael Norman Journal: Am J Clin Nutr Date: 2014-01-08 Impact factor: 7.045
Authors: Ghattu V Krishnaveni; Sargoor R Veena; Nicola R Winder; Jacqueline C Hill; Kate Noonan; Barbara J Boucher; Samuel C Karat; Caroline H D Fall Journal: Am J Clin Nutr Date: 2011-01-12 Impact factor: 7.045