Literature DB >> 30352173

Promoting Diversity in the Cytoskeleton through STEM-Structural Transitions and Energetics of Microtubule Subunits.

Ryoma Ohi1, Kristen J Verhey2.   

Abstract

All microtubules assemble from tubulin subunits, but the functional impact of tubulin isotypes has been unclear. Reporting in Developmental Cell, Chaaban et al. (2018) and Ti et al. (2018) show that tubulin isotypes differ in their conformational flexibility, which alters microtubule dynamics and architecture, yet maintain "lock-and-key" interactions with neighbors.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30352173      PMCID： PMC6396305          DOI： 10.1016/j.devcel.2018.10.008

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

1.  Overexpression, purification, and functional analysis of recombinant human tubulin dimer.

Authors:  Itsushi Minoura; You Hachikubo; Yoshihiko Yamakita; Hiroko Takazaki; Rie Ayukawa; Seiichi Uchimura; Etsuko Muto
Journal:  FEBS Lett       Date:  2013-09-08       Impact factor: 4.124

2.  The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth.

Authors:  Sami Chaaban; Shashank Jariwala; Chieh-Ting Hsu; Stefanie Redemann; Justin M Kollman; Thomas Müller-Reichert; David Sept; Khanh Huy Bui; Gary J Brouhard
Journal:  Dev Cell       Date:  2018-09-20       Impact factor: 12.270

3.  Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.

Authors:  Shih-Chieh Ti; Gregory M Alushin; Tarun M Kapoor
Journal:  Dev Cell       Date:  2018-09-20       Impact factor: 12.270

4.  One-step purification of assembly-competent tubulin from diverse eukaryotic sources.

Authors:  Per O Widlund; Marija Podolski; Simone Reber; Joshua Alper; Marko Storch; Anthony A Hyman; Jonathon Howard; David N Drechsel
Journal:  Mol Biol Cell       Date:  2012-09-19       Impact factor: 4.138

5.  A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics.

Authors:  Elisabeth A Geyer; Alexander Burns; Beth A Lalonde; Xuecheng Ye; Felipe-Andres Piedra; Tim C Huffaker; Luke M Rice
Journal:  Elife       Date:  2015-10-06       Impact factor: 8.140

6.  Microtubule architecture in vitro and in cells revealed by cryo-electron tomography.

Authors:  Joseph Atherton; Melissa Stouffer; Fiona Francis; Carolyn A Moores
Journal:  Acta Crystallogr D Struct Biol       Date:  2018-04-11       Impact factor: 7.652

7.  Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.

Authors:  Shih-Chieh Ti; Melissa C Pamula; Stuart C Howes; Christian Duellberg; Nicholas I Cade; Ralph E Kleiner; Scott Forth; Thomas Surrey; Eva Nogales; Tarun M Kapoor
Journal:  Dev Cell       Date:  2016-04-04       Impact factor: 12.270

8.  The structured core of human β tubulin confers isotype-specific polymerization properties.

Authors:  Melissa C Pamula; Shih-Chieh Ti; Tarun M Kapoor
Journal:  J Cell Biol       Date:  2016-05-16       Impact factor: 10.539

9.  Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.

Authors:  Annapurna Vemu; Joseph Atherton; Jeffrey O Spector; Agnieszka Szyk; Carolyn A Moores; Antonina Roll-Mecak
Journal:  J Biol Chem       Date:  2016-04-25       Impact factor: 5.157

10.  Tubulin isoform composition tunes microtubule dynamics.

Authors:  Annapurna Vemu; Joseph Atherton; Jeffrey O Spector; Carolyn A Moores; Antonina Roll-Mecak
Journal:  Mol Biol Cell       Date:  2017-10-11       Impact factor: 4.138
  10 in total

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