Literature DB >> 30350109

Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma.

Yoshiko Nakano1,2, Arata Tomiyama3,4, Takashi Kohno5, Akihiko Yoshida6, Kai Yamasaki3,7, Tatsuya Ozawa3, Kohei Fukuoka3, Hiroko Fukushima8, Takeshi Inoue8, Junichi Hara7, Hiroaki Sakamoto9, Koichi Ichimura3.   

Abstract

The proto-oncogene tyrosine-protein kinase ROS1 (ROS1) is a tyrosine kinase that is closely related to anaplastic lymphoma kinase receptor (ALK). We describe a novel KLC1-ROS1 fusion identified in a case of pediatric low-grade glioma. This was detected by RNA sequencing and confirmed by reverse-transcription PCR and fluorescent in situ hybridization. Immunohistochemical staining for ROS1 was positive in the tumor cytoplasm. In vitro analysis demonstrated the oncogenic activity of this fusion, which was suppressed by the ALK/ROS1 inhibitor, crizotinib. Our case and others suggest that various ROS1 fusions might be present in a subset of pediatric gliomas, which could be targeted for therapy.

Entities:  

Keywords:  Crizotinib; FISH; Immunohistochemistry; KLC1–ROS1 fusion; Pediatric glioma

Mesh：

Substances：

Year:  2018        PMID： 30350109     DOI： 10.1007/s10014-018-0330-3

Source DB:  PubMed          Journal:  Brain Tumor Pathol        ISSN： 1433-7398            Impact factor:   3.298


  5 in total

Review 1.  Molecular alterations of low-grade gliomas in young patients: Strategies and platforms for routine evaluation.

Authors:  Iman Dandapath; Rituparna Chakraborty; Kavneet Kaur; Swati Mahajan; Jyotsna Singh; Mehar C Sharma; Chitra Sarkar; Vaishali Suri
Journal:  Neurooncol Pract       Date:  2021-08-23

2.  Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:  Matthew Clarke; Alan Mackay; Britta Ismer; Jessica C Pickles; Ruth G Tatevossian; Scott Newman; Tejus A Bale; Iris Stoler; Elisa Izquierdo; Sara Temelso; Diana M Carvalho; Valeria Molinari; Anna Burford; Louise Howell; Alex Virasami; Amy R Fairchild; Aimee Avery; Jane Chalker; Mark Kristiansen; Kelly Haupfear; James D Dalton; Wilda Orisme; Ji Wen; Michael Hubank; Kathreena M Kurian; Catherine Rowe; Mellissa Maybury; Stephen Crosier; Jeffrey Knipstein; Ulrich Schüller; Uwe Kordes; David E Kram; Matija Snuderl; Leslie Bridges; Andrew J Martin; Lawrence J Doey; Safa Al-Sarraj; Christopher Chandler; Bassel Zebian; Claire Cairns; Rachael Natrajan; Jessica K R Boult; Simon P Robinson; Martin Sill; Ira J Dunkel; Stephen W Gilheeney; Marc K Rosenblum; Debbie Hughes; Paula Z Proszek; Tobey J Macdonald; Matthias Preusser; Christine Haberler; Irene Slavc; Roger Packer; Ho-Keung Ng; Shani Caspi; Mara Popović; Barbara Faganel Kotnik; Matthew D Wood; Lissa Baird; Monika Ashok Davare; David A Solomon; Thale Kristin Olsen; Petter Brandal; Michael Farrell; Jane B Cryan; Michael Capra; Michael Karremann; Jens Schittenhelm; Martin U Schuhmann; Martin Ebinger; Winand N M Dinjens; Kornelius Kerl; Simone Hettmer; Torsten Pietsch; Felipe Andreiuolo; Pablo Hernáiz Driever; Andrey Korshunov; Lotte Hiddingh; Barbara C Worst; Dominik Sturm; Marc Zuckermann; Olaf Witt; Tabitha Bloom; Clare Mitchell; Evelina Miele; Giovanna Stefania Colafati; Francesca Diomedi-Camassei; Simon Bailey; Andrew S Moore; Timothy E G Hassall; Stephen P Lowis; Maria Tsoli; Mark J Cowley; David S Ziegler; Matthias A Karajannis; Kristian Aquilina; Darren R Hargrave; Fernando Carceller; Lynley V Marshall; Andreas von Deimling; Christof M Kramm; Stefan M Pfister; Felix Sahm; Suzanne J Baker; Angela Mastronuzzi; Andrea Carai; Maria Vinci; David Capper; Sergey Popov; David W Ellison; Thomas S Jacques; David T W Jones; Chris Jones
Journal:  Cancer Discov       Date:  2020-04-01       Impact factor: 39.397

Review 3.  Pediatric low-grade glioma in the era of molecular diagnostics.

Authors:  Scott Ryall; Uri Tabori; Cynthia Hawkins
Journal:  Acta Neuropathol Commun       Date:  2020-03-12       Impact factor: 7.801

4.  GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.

Authors:  Philipp Sievers; Damian Stichel; Martin Sill; Daniel Schrimpf; Dominik Sturm; Florian Selt; Jonas Ecker; Daniel Kazdal; Evelina Miele; Mariëtte E G Kranendonk; Bastiaan B J Tops; Patricia Kohlhof-Meinecke; Rudi Beschorner; Christof M Kramm; Martin Hasselblatt; Guido Reifenberger; David Capper; Pieter Wesseling; Albrecht Stenzinger; Till Milde; Andrey Korshunov; Olaf Witt; Stefan M Pfister; Wolfgang Wick; Andreas von Deimling; David T W Jones; Felix Sahm
Journal:  Acta Neuropathol       Date:  2021-09-18       Impact factor: 17.088

Review 5.  The oncogenic fusion landscape in pediatric CNS neoplasms.

Authors:  Mieke Roosen; Zelda Odé; Jens Bunt; Marcel Kool
Journal:  Acta Neuropathol       Date:  2022-02-15       Impact factor: 15.887
  5 in total

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