Literature DB >> 30350013

Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

Christina Durón1, Yuan Pan2, David H Gutmann3, Johanna Hardin4, Ami Radunskaya5.   

Abstract

This paper begins to build a theoretical framework that would enable the pharmaceutical industry to use network complexity measures as a way to identify drug targets. The variability of a betweenness measure for a network node is examined through different methods of network perturbation. Our results indicate a robustness of betweenness centrality in the identification of target genes.

Entities:  

Keywords:  Betweenness centrality; Differential expression; Network complexity measure

Year:  2018        PMID： 30350013      PMCID： PMC6476710          DOI： 10.1007/s11538-018-0526-z

Source DB:  PubMed          Journal:  Bull Math Biol        ISSN： 0092-8240            Impact factor:   1.758


  33 in total

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2.  Lethality and centrality in protein networks.

Authors:  H Jeong; S P Mason; A L Barabási; Z N Oltvai
Journal:  Nature       Date:  2001-05-03       Impact factor: 49.962

3.  Evidence for dynamically organized modularity in the yeast protein-protein interaction network.

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Journal:  Nature       Date:  2004-06-09       Impact factor: 49.962

4.  Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression.

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Journal:  Int J Mol Med       Date:  2005-05       Impact factor: 4.101

5.  Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.

Authors:  Igor Jakovcevski; Nada Zecevic
Journal:  J Neurosci       Date:  2005-11-02       Impact factor: 6.167

6.  Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.

Authors:  Faith B Davis; Heng-Yuan Tang; Ai Shih; Travis Keating; Lawrence Lansing; Aleck Hercbergs; Robert A Fenstermaker; Ahmed Mousa; Shaker A Mousa; Paul J Davis; Hung-Yun Lin
Journal:  Cancer Res       Date:  2006-07-15       Impact factor: 12.701

7.  Rembrandt: helping personalized medicine become a reality through integrative translational research.

Authors:  Subha Madhavan; Jean-Claude Zenklusen; Yuri Kotliarov; Himanso Sahni; Howard A Fine; Kenneth Buetow
Journal:  Mol Cancer Res       Date:  2009-02-10       Impact factor: 5.852

8.  Expression of SoxE and SoxD genes in human gliomas.

Authors:  B Schlierf; R P Friedrich; P Roerig; J Felsberg; G Reifenberger; M Wegner
Journal:  Neuropathol Appl Neurobiol       Date:  2007-10-24       Impact factor: 8.090

9.  Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.

Authors:  Biagio Azzarelli; Leticia Miravalle; Ruben Vidal
Journal:  J Neuropathol Exp Neurol       Date:  2004-02       Impact factor: 3.685

10.  ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

Authors:  Adam A Margolin; Ilya Nemenman; Katia Basso; Chris Wiggins; Gustavo Stolovitzky; Riccardo Dalla Favera; Andrea Califano
Journal:  BMC Bioinformatics       Date:  2006-03-20       Impact factor: 3.169
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2.  Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing.

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3.  Gene Expression Monotonicity across Bladder Cancer Stages Informs on the Molecular Pathogenesis and Identifies a Prognostic Eight-Gene Signature.

Authors:  Rafael Stroggilos; Maria Frantzi; Jerome Zoidakis; Marika Mokou; Napoleon Moulavasilis; Emmanouil Mavrogeorgis; Anna Melidi; Manousos Makridakis; Konstantinos Stravodimos; Maria G Roubelakis; Harald Mischak; Antonia Vlahou
Journal:  Cancers (Basel)       Date:  2022-05-21       Impact factor: 6.575

4.  What Can Mathematics Do for Drug Development?

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Journal:  Bull Math Biol       Date:  2019-09       Impact factor: 1.758
  4 in total

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