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Literature DB >> 30349111

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.

Mu Zhou¹, Zhihui Liu^2,3, Maxwell D Melin², Yi Han Ng², Wei Xu^2,4, Thomas C Südhof^5,6.

Abstract

The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2018 PMID： 30349111 PMCID： PMC7261007 DOI： 10.1038/s41593-018-0248-4

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

25 in total

1. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice.

Authors: Gisella Vetere; Justin W Kenney; Lina M Tran; Frances Xia; Patrick E Steadman; John Parkinson; Sheena A Josselyn; Paul W Frankland
Journal: Neuron Date: 2017-04-19 Impact factor: 17.173

2. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.

Authors: Kai Liu; Juhyun Kim; Dong Won Kim; Yi Stephanie Zhang; Hechen Bao; Myrto Denaxa; Szu-Aun Lim; Eileen Kim; Chang Liu; Ian R Wickersham; Vassilis Pachnis; Samer Hattar; Juan Song; Solange P Brown; Seth Blackshaw
Journal: Nature Date: 2017-08-23 Impact factor: 49.962

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.

1. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice.

2. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.

3. Roles of Cbln1 in Non-Motor Functions of Mice.

4. Warning! Dopaminergic Modulation of the Superior Colliculus.

Review 5. The neuroscience of mammalian associative learning.

6. A temporal shift in the circuits mediating retrieval of fear memory.

7. The paraventricular thalamus controls a central amygdala fear circuit.

8. Vision Guides Selection of Freeze or Flight Defense Strategies in Mice.

9. Identification of a functional connectome for long-term fear memory in mice.

10. Inhibitory gain modulation of defense behaviors by zona incerta.

1. Modulation of fear generalization by the zona incerta.

2. Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats.

3. Nucleus reuniens mediates the extinction of contextual fear conditioning.

4. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.

Review 5. Embracing Complexity in Defensive Networks.

Review 6. Neural circuit control of innate behaviors.

Review 7. Zona Incerta: An Integrative Node for Global Behavioral Modulation.

8. Persistent transcriptional programmes are associated with remote memory.

9. Reconsolidation of a post-ingestive nutrient memory requires mTOR in the central amygdala.

10. Incerto-thalamic modulation of fear via GABA and dopamine.