Ioannis Nakos1, Nikolaos P E Kadoglou2,3, Paraskevi Gkeka2, Alexandros T Tzallas4, Nikolaos Giannakeas4, Dimitrios G Tsalikakis5, Michalis Katsimpoulas2, Georgios Mantziaras2, Nikolaos Kostomitsopoulos2, Christos D Liapis2,6, John Kakisis2,6. 1. Biomedical Research Foundation, Center of Clinical, Experimental Surgery, and Translational Research, Academy of Athens, Athens, Greece ioannisnakos78@gmail.com. 2. Biomedical Research Foundation, Center of Clinical, Experimental Surgery, and Translational Research, Academy of Athens, Athens, Greece. 3. The Heart Hospital, University College London, London, U.K. 4. Department of Computer Engineering, School of Applied Technology, Technological Educational Institute of Epirus, Arta, Greece. 5. Research and Analysis Laboratory, Department of Informatics and Telecommunication Engineering, University of Western Macedonia, Kozani, Greece. 6. Athens Medical Center, Vascular and Endovascular Surgery Clinic, Athens, Greece.
Abstract
BACKGROUND/AIM: Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabetic rats. MATERIALS AND METHODS: Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p<0.001) and R-wave amplitude (p<0.05). Frequency-domain spectral variables were also analyzed. The SD group had a significantly lower absolute high-frequency component (p<0.05) and higher normalized low-frequency component, as well as low-frequency power divided by the high-frequency power ratio when compared to the SC and EC groups (p<0.05). All these diabetes-related adverse changes in heart rate variability parameters were significantly reversed by exercise training (p<0.05). Overall, our study shows that early initiation of systemic exercise training prevents the development of cardiac autonomic neuropathy in rats with type 1 diabetes mellitus, by favorable change in the balance between parasympathetic and sympathetic activity. Copyright
BACKGROUND/AIM: Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabeticrats. MATERIALS AND METHODS:Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p<0.001) and R-wave amplitude (p<0.05). Frequency-domain spectral variables were also analyzed. The SD group had a significantly lower absolute high-frequency component (p<0.05) and higher normalized low-frequency component, as well as low-frequency power divided by the high-frequency power ratio when compared to the SC and EC groups (p<0.05). All these diabetes-related adverse changes in heart rate variability parameters were significantly reversed by exercise training (p<0.05). Overall, our study shows that early initiation of systemic exercise training prevents the development of cardiac autonomic neuropathy in rats with type 1 diabetes mellitus, by favorable change in the balance between parasympathetic and sympathetic activity. Copyright
Authors: Triantaffilos P Didangelos; Georgios A Arsos; Dimitrios T Karamitsos; Vasilios G Athyros; Nikolaos D Karatzas Journal: Diabetes Care Date: 2003-07 Impact factor: 19.112
Authors: K L De Angelis; A R Oliveira; P Dall'Ago; L R Peixoto; G Gadonski; S Lacchini; T G Fernandes; M C Irigoyen Journal: Braz J Med Biol Res Date: 2000-06 Impact factor: 2.590
Authors: K De Angelis Lobo d'Avila; G Gadonski; J Fang; P Dall'Ago; V L Albuquerque; L R Peixoto; T G Fernandes; M C Irigoyen Journal: Hypertension Date: 1999-10 Impact factor: 10.190