| Literature DB >> 3034846 |
T Ando, S Okada, I Uchida, K Hemmi, M Nishikawa, Y Tsurumi, A Fujie, K Yoshida, M Okuhara.
Abstract
WF-10129 is an angiotensin converting enzyme (ACE) inhibitor produced by Doratomyces putredinis. IC50 of the compound is 1.4 X 10(-8) M for the ACE activity. WF-10129 was purified from cultured filtrate by successive ion exchange chromatography and HPLC. The chemical structure 1 was elucidated on the basis of spectroscopic and chemical evidence. The compound is a dipeptide composed of L-tyrosine and a novel amino acid. WF-10129 inhibits the pressor response of angiotensin I when administered intravenously at 0.3 mg/kg in rats.Entities:
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Year: 1987 PMID： 3034846 DOI： 10.7164/antibiotics.40.468
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649