Literature DB >> 30347517

Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B.

Peng Chen1, Liang Tao2,3,4, Zheng Liu1, Min Dong2,3,4, Rongsheng Jin1.   

Abstract

The incidence of Clostridium difficile infection (CDI) has increased significantly worldwide, causing substantial morbidity and mortality. One of the major virulence factor, TcdB, manages to enter the colonic epithelia via the human frizzled proteins (FZDs), which are physiological receptors for Wnt morphogens. Binding of TcdB to FZDs inhibits Wnt signaling, which may contribute to pathogenesis of CDI. Here, we review the structural mechanism by which TcdB exploits to recognize FZDs for cell entry and inhibiting Wnt signaling, which reveals new strategies to modulate Wnt signaling for therapeutic interventions.
© 2018 Federation of European Biochemical Societies.

Entities:  

Keywords:  zzm321990Clostridium difficilezzm321990; Clostridium difficile infection; Wnt signaling; bacterial toxin; cancers; frizzled; host-pathogen interactions

Mesh：

Substances：

Year:  2018        PMID： 30347517      PMCID： PMC6399045          DOI： 10.1111/febs.14681

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  34 in total

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  6 in total

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