Blessing O Ahiante1, Wayne Smith1,2, Leandi Lammertyn1,2, Aletta E Schutte1,2. 1. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. 2. Medical Research Council: Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Abstract
BACKGROUND AND AIM: Information regarding the effect of leptin on the vasculature in young healthy adults at risk for cardiovascular disease development is limited. We therefore examined the associations between measures of subclinical atherosclerosis (carotid intima-media thickness, carotid cross-sectional wall area), large artery stiffness (pulse wave velocity) and a measure of endothelial dysfunction (von Willebrand factor [vWF]) with leptin in young healthy men and women. METHODS: In a cross-sectional study in South Africa involving 820 normotensive individuals (337 men and 483 women) aged 20-30 years, we measured carotid intima-media thickness, carotid cross-sectional wall area, pulse wave velocity, vWF from citrated plasma and leptin from serum. RESULTS: Despite sevenfold higher leptin in women than men (P < 0.001), only in young healthy men, we observed negative, independent associations between measures of carotid wall thickness (carotid intima-media thickness: R2 = 0.05; β = -0.20; P = 0.036; carotid cross-sectional wall area: R2 = 0.05; β = -0.20; P = 0.035) with leptin in multivariable-adjusted regression analyses. When reviewing these associations across body mass index categories, we found an association to be evident only in overweight men (carotid intima-media thickness: R2 = 0.15; β = -0.41; P = 0.007; carotid cross-sectional wall area: R2 = 0.21; β = -0.47; P = 0.002). No association was observed in the women or between pulse wave velocity and vWF with leptin. CONCLUSION: In young healthy men, we found a beneficial inverse association between measures of carotid wall thickness and circulating leptin, thereby supporting a potential vascular protective role of leptin.
BACKGROUND AND AIM: Information regarding the effect of leptin on the vasculature in young healthy adults at risk for cardiovascular disease development is limited. We therefore examined the associations between measures of subclinical atherosclerosis (carotid intima-media thickness, carotid cross-sectional wall area), large artery stiffness (pulse wave velocity) and a measure of endothelial dysfunction (von Willebrand factor [vWF]) with leptin in young healthy men and women. METHODS: In a cross-sectional study in South Africa involving 820 normotensive individuals (337 men and 483 women) aged 20-30 years, we measured carotid intima-media thickness, carotid cross-sectional wall area, pulse wave velocity, vWF from citrated plasma and leptin from serum. RESULTS: Despite sevenfold higher leptin in women than men (P < 0.001), only in young healthy men, we observed negative, independent associations between measures of carotid wall thickness (carotid intima-media thickness: R2 = 0.05; β = -0.20; P = 0.036; carotid cross-sectional wall area: R2 = 0.05; β = -0.20; P = 0.035) with leptin in multivariable-adjusted regression analyses. When reviewing these associations across body mass index categories, we found an association to be evident only in overweight men (carotid intima-media thickness: R2 = 0.15; β = -0.41; P = 0.007; carotid cross-sectional wall area: R2 = 0.21; β = -0.47; P = 0.002). No association was observed in the women or between pulse wave velocity and vWF with leptin. CONCLUSION: In young healthy men, we found a beneficial inverse association between measures of carotid wall thickness and circulating leptin, thereby supporting a potential vascular protective role of leptin.
Authors: Susan A Everson-Rose; Emma J M Barinas-Mitchell; Samar R El Khoudary; Hsin-Hui Huang; Qi Wang; Imke Janssen; Rebecca C Thurston; Elizabeth A Jackson; Melissa E Lewis; Carrie Karvonen-Gutierrez; Peter Mancuso; Carol A Derby Journal: J Am Heart Assoc Date: 2021-03-27 Impact factor: 5.501
Authors: Paulina Elena Stürzebecher; Susan Kralisch; Marie Ruth Schubert; Vanina Filipova; Annett Hoffmann; Fabiana Oliveira; Bilal N Sheikh; Matthias Blüher; Alexander Kogel; Markus Scholz; Karoline Elizabeth Kokot; Stephan Erbe; Jasmin Marga Kneuer; Thomas Ebert; Mathias Fasshauer; Konstanze Miehle; Ulrich Laufs; Anke Tönjes; Jes-Niels Boeckel Journal: Proc Natl Acad Sci U S A Date: 2022-09-26 Impact factor: 12.779