Anne-Sophie Mariet1, Frédéric Mauny2, Sophie Pujol3, Gérard Thiriez4, Paul Sagot5, Didier Riethmuller6, Mathieu Boilleaut7, Jérôme Defrance8, Hélène Houot9, Anne-Laure Parmentier3, Marie Vasseur-Barba3, Eric Benzenine10, Catherine Quantin1, Nadine Bernard11. 1. CHU Dijon Bourgogne, Service de Biostatistiques et d'Information Médicale, F-21000 Dijon, France; CHU Dijon Bourgogne, Inserm, Clinical Investigation Center of Dijon (Inserm CIC 1432), F-21000 Dijon, France; Université Bourgogne Franche-Comté, Inserm, Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses (B2PHI), UMR 1181, F-21000 Dijon, France. 2. CHU de Besançon, Unité de Méthodologie en Recherche Clinique, Épidémiologie et Santé Publique, INSERM CIC 1431, F-25000 Besançon, France; Université de Bourgogne Franche-Comté, CNRS, Laboratoire Chrono-Environnement UMR 6249, F-25000 Besançon, France. Electronic address: frederic.mauny@univ-fcomte.fr. 3. CHU de Besançon, Unité de Méthodologie en Recherche Clinique, Épidémiologie et Santé Publique, INSERM CIC 1431, F-25000 Besançon, France; Université de Bourgogne Franche-Comté, CNRS, Laboratoire Chrono-Environnement UMR 6249, F-25000 Besançon, France. 4. CHU de Besançon, Service de Réanimation Pédiatrique, Néonatalogie et Urgences Pédiatriques, F-25000 Besançon, France. 5. CHU Dijon Bourgogne, Service de Gynécologie-Obstétrique, F-21000 Dijon, France. 6. CHU de Besançon, Service de Gynécologie-Obstétrique, F-25000 Besançon, France. 7. Atmo Bourgogne-Franche-Comté, F-25000 Besançon, France. 8. Centre Scientifique et Technique du Bâtiment, Pôle Acoustique et Eclairage, F-38400 Saint Martin d'Hères, France. 9. Université de Bourgogne Franche-Comté, CNRS, Laboratoire ThéMA UMR 6049, F-25000 Besançon, France. 10. CHU Dijon Bourgogne, Service de Biostatistiques et d'Information Médicale, F-21000 Dijon, France; CHU Dijon Bourgogne, Inserm, Clinical Investigation Center of Dijon (Inserm CIC 1432), F-21000 Dijon, France. 11. Université de Bourgogne Franche-Comté, CNRS, Laboratoire Chrono-Environnement UMR 6249, F-25000 Besançon, France; Université de Bourgogne Franche-Comté, CNRS, Laboratoire ThéMA UMR 6049, F-25000 Besançon, France.
Abstract
BACKGROUND: Multiple pregnancies (where more than one fetus develops simultaneously in the womb) are systematically excluded from studies of the impact of air pollution on pregnancy outcomes. This study aims to analyze, in a population of multiple pregnancies, the relationship between fetal growth restriction (FGR), small for gestational age (SGA) and exposure to air pollution in moderately polluted cities. METHODS: All women with multiple pregnancies living in the city of Besançon or in the urban area of Dijon and who delivered at a university hospital between 2005 and 2009 were included. FGR and SGA were obtained from medical records. Outdoor residential nitrogen dioxide (NO2) exposure was assessed using the mother's address, considering a 50 m radius buffer over the following defined pregnancy periods: each trimester, entire pregnancy and two months before delivery. Logistic regression analyses were performed. RESULTS: This study included 249 multiple pregnancies with 506 newborns. The median of NO2 concentration considering a 50 m radius buffer during entire pregnancy was 23.1 μg/m3 (minimum at 10.1 μg/m3 and maximum at 46.7 μg/m3). No association was observed between NO2 and SGA whatever the pregnancy period (the odds ratio (OR) range 0.78 to 0.88). Regarding FGR, the OR associated with an increase of 10 μg/m3 of NO2 exposure during entire pregnancy was 1.52 (95% Confidence Interval (CI): 1.02-2.26). Similar results were observed for NO2 exposure during the various pregnancy periods. CONCLUSIONS: These results are in line with an association between NO2 and fetal growth in multiple pregnancies for an exposure mostly below the threshold set out in European legislation.
BACKGROUND: Multiple pregnancies (where more than one fetus develops simultaneously in the womb) are systematically excluded from studies of the impact of air pollution on pregnancy outcomes. This study aims to analyze, in a population of multiple pregnancies, the relationship between fetal growth restriction (FGR), small for gestational age (SGA) and exposure to air pollution in moderately polluted cities. METHODS: All women with multiple pregnancies living in the city of Besançon or in the urban area of Dijon and who delivered at a university hospital between 2005 and 2009 were included. FGR and SGA were obtained from medical records. Outdoor residential nitrogen dioxide (NO2) exposure was assessed using the mother's address, considering a 50 m radius buffer over the following defined pregnancy periods: each trimester, entire pregnancy and two months before delivery. Logistic regression analyses were performed. RESULTS: This study included 249 multiple pregnancies with 506 newborns. The median of NO2 concentration considering a 50 m radius buffer during entire pregnancy was 23.1 μg/m3 (minimum at 10.1 μg/m3 and maximum at 46.7 μg/m3). No association was observed between NO2 and SGA whatever the pregnancy period (the odds ratio (OR) range 0.78 to 0.88). Regarding FGR, the OR associated with an increase of 10 μg/m3 of NO2 exposure during entire pregnancy was 1.52 (95% Confidence Interval (CI): 1.02-2.26). Similar results were observed for NO2 exposure during the various pregnancy periods. CONCLUSIONS: These results are in line with an association between NO2 and fetal growth in multiple pregnancies for an exposure mostly below the threshold set out in European legislation.
Authors: Zheng Li; Jianqing Ma; Jianxiong Shen; Matthew T V Chan; William K K Wu; Zhanyong Wu Journal: Environ Sci Pollut Res Int Date: 2019-10-21 Impact factor: 4.223
Authors: Valentin Simoncic; Christophe Enaux; Séverine Deguen; Wahida Kihal-Talantikite Journal: Int J Environ Res Public Health Date: 2020-11-03 Impact factor: 3.390