Thomas Dietenbeck1, Damian Craiem2, David Rosenbaum3, Alain Giron4, Alain De Cesare4, Kévin Bouaou4, Xavier Girerd5, Philippe Cluzel6, Alban Redheuil6, Nadjia Kachenoura4. 1. Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), F-75006, Paris, France. Electronic address: thomas.dietenbeck@sorbonne-universite.fr. 2. Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina. 3. Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), F-75006, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Imaging Core Lab, Paris, France. 4. Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), F-75006, Paris, France. 5. ICAN Institute of Cardiometabolism and Nutrition, Imaging Core Lab, Paris, France. 6. Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), F-75006, Paris, France; ICAN Institute of Cardiometabolism and Nutrition, Imaging Core Lab, Paris, France; Département d'imagerie cardiovasculaire DICVRIT, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière APHP, Paris, France.
Abstract
BACKGROUND: Clinically, aortic geometry assessment is mainly based on the measurement of maximal diameters at different anatomic locations, which are subsequently used to indicate prophylactic aortic surgery. However, 3D evaluation of aortic morphology could provide volumetric quantification, which integrates both aortic dilatation and elongation and might thus be more sensitive to early geometric changes than diameters. Precise aortic morphology is also required for the calculation of pulse wave velocity (PWVMRI), an established marker of aortic stiffness. Accordingly, we proposed a 3D semi-automated analysis of thoracic aorta MRI data optimizing morphological and subsequent stiffness assessment. METHODS: We studied 74 individuals (40 males, 50 ± 12years): 21 healthy volunteers and 53 patients with hypertension in whom aortic 3D MRI angiography and 2D + t phase-contrast and cine imaging were performed. A semi-automated method was proposed for volumetric aortic segmentation and was evaluated by studying resulting measurements (length, diameters, volumes and PWVMRI) in terms of: 1) reproducibility, 2) correlations with well-established 2D aortic length and diameters, 3) associations with age, carotid-femoral PWV (cf-PWV) and presence of hypertension. RESULTS: The measurements obtained with the proposed method were reproducible (coefficients of variation ≤ 5.1%) and were highly correlated with 2D measurements (arch length: r = 0.80, Bland-Altman mean bias [limits]: 2.7 mm [-25; 30]; PWVMRI: r = 0.95, 0.22 m/s [-1.9; 2.4]). Higher or similar correlations with age were found for the proposed 3D method compared to the 2D approach (arch length: r = 0.47 (2D), r = 0.60 (3D); PWVMRI: r = 0.63 (2D), r = 0.64 (3D)). Moreover, a significant association was found between PWVMRI and cf-PWV (r = 0.49, p < 0.001). All aortic measurements increased with hypertension (p < 0.05) and with age: arch length (+9mm/decade); diameters: ascending (+1.2mm/decade) and descending aorta (+1.0mm/decade); volumes: ascending (+2.6mL/decade) and descending aorta (+4.0mL/decade); PWVMRI (+1.7 m s-1/decade). CONCLUSIONS: A semi-automated method based on cylindrical active surfaces was proposed for the 3D segmentation of the aorta using a single MRI dataset, providing aortic diameters at anatomical landmarks, aortic volumes and the aortic centerline length used for PWV estimation. Such measurements were reproducible and comparable to expert measurements, which required time-consuming centerline delineation. Furthermore, expected relationships with age and hypertension were found indicating the consistency of our measurements.
BACKGROUND: Clinically, aortic geometry assessment is mainly based on the measurement of maximal diameters at different anatomic locations, which are subsequently used to indicate prophylactic aortic surgery. However, 3D evaluation of aortic morphology could provide volumetric quantification, which integrates both aortic dilatation and elongation and might thus be more sensitive to early geometric changes than diameters. Precise aortic morphology is also required for the calculation of pulse wave velocity (PWVMRI), an established marker of aortic stiffness. Accordingly, we proposed a 3D semi-automated analysis of thoracic aorta MRI data optimizing morphological and subsequent stiffness assessment. METHODS: We studied 74 individuals (40 males, 50 ± 12years): 21 healthy volunteers and 53 patients with hypertension in whom aortic 3D MRI angiography and 2D + t phase-contrast and cine imaging were performed. A semi-automated method was proposed for volumetric aortic segmentation and was evaluated by studying resulting measurements (length, diameters, volumes and PWVMRI) in terms of: 1) reproducibility, 2) correlations with well-established 2D aortic length and diameters, 3) associations with age, carotid-femoral PWV (cf-PWV) and presence of hypertension. RESULTS: The measurements obtained with the proposed method were reproducible (coefficients of variation ≤ 5.1%) and were highly correlated with 2D measurements (arch length: r = 0.80, Bland-Altman mean bias [limits]: 2.7 mm [-25; 30]; PWVMRI: r = 0.95, 0.22 m/s [-1.9; 2.4]). Higher or similar correlations with age were found for the proposed 3D method compared to the 2D approach (arch length: r = 0.47 (2D), r = 0.60 (3D); PWVMRI: r = 0.63 (2D), r = 0.64 (3D)). Moreover, a significant association was found between PWVMRI and cf-PWV (r = 0.49, p < 0.001). All aortic measurements increased with hypertension (p < 0.05) and with age: arch length (+9mm/decade); diameters: ascending (+1.2mm/decade) and descending aorta (+1.0mm/decade); volumes: ascending (+2.6mL/decade) and descending aorta (+4.0mL/decade); PWVMRI (+1.7 m s-1/decade). CONCLUSIONS: A semi-automated method based on cylindrical active surfaces was proposed for the 3D segmentation of the aorta using a single MRI dataset, providing aortic diameters at anatomical landmarks, aortic volumes and the aortic centerline length used for PWV estimation. Such measurements were reproducible and comparable to expert measurements, which required time-consuming centerline delineation. Furthermore, expected relationships with age and hypertension were found indicating the consistency of our measurements.