Henrik Øder Hjortkjær1,2, Tonny Jensen2, Jannik Hilsted2, Ulrik Madvig Mogensen1, Peter Rossing3,4, Lars Køber1,3, Klaus Fuglsang Kofoed1,5. 1. 1 Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, København, Denmark. 2. 2 Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, København, Denmark. 3. 3 Steno Diabetes Center Copenhagen, Gentofte, Denmark. 4. 4 Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark. 5. 5 Department of Diagnostic Radiology, Rigshospitalet, Copenhagen University Hospital, København, Denmark.
Abstract
BACKGROUND: Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardiovascular events; the aim of this study was to investigate the level of generalised arterial calcification in patients with long-term, normoalbuminuric type 1 diabetes and the association with cardiovascular autonomic neuropathy, as these factors have not been investigated in type 1 diabetes. METHODS: Participants were examined for calcification of coronary and carotid arteries through non-contrast multi-detector computed tomography scans. Generalised arterial calcification was defined as the presence of calcium in both the coronary and carotid arteries. RESULTS: A total of 53 patients with type 1 diabetes were included. Coronary and carotid artery calcium scores were correlated ( r = 0.720, p < 0.0001). Cardiovascular autonomic neuropathy was associated with increased coronary ( p = 0.002) and carotid ( p = 0.001) artery calcium scores. Seventeen of 20 patients with cardiovascular autonomic neuropathy (85%) demonstrated generalised arterial calcification compared to 11 (33%) patients without cardiovascular autonomic neuropathy; patients with cardiovascular autonomic neuropathy had an odds ratio of 11.3 (95% confidence interval = 2.7-47.1, p < 0.001) for generalised arterial calcification. CONCLUSION: Cardiovascular autonomic neuropathy is associated with increased level of generalised arterial calcification in patients with normoalbuminuric, long-term type 1 diabetes.
BACKGROUND:Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardiovascular events; the aim of this study was to investigate the level of generalised arterial calcification in patients with long-term, normoalbuminuric type 1 diabetes and the association with cardiovascular autonomic neuropathy, as these factors have not been investigated in type 1 diabetes. METHODS:Participants were examined for calcification of coronary and carotid arteries through non-contrast multi-detector computed tomography scans. Generalised arterial calcification was defined as the presence of calcium in both the coronary and carotid arteries. RESULTS: A total of 53 patients with type 1 diabetes were included. Coronary and carotid artery calcium scores were correlated ( r = 0.720, p < 0.0001). Cardiovascular autonomic neuropathy was associated with increased coronary ( p = 0.002) and carotid ( p = 0.001) artery calcium scores. Seventeen of 20 patients with cardiovascular autonomic neuropathy (85%) demonstrated generalised arterial calcification compared to 11 (33%) patients without cardiovascular autonomic neuropathy; patients with cardiovascular autonomic neuropathy had an odds ratio of 11.3 (95% confidence interval = 2.7-47.1, p < 0.001) for generalised arterial calcification. CONCLUSION:Cardiovascular autonomic neuropathy is associated with increased level of generalised arterial calcification in patients with normoalbuminuric, long-term type 1 diabetes.
Authors: Ida Maria Hjelm Sørensen; Sasha Asbøll Kepler Saurbrey; Henrik Øder Hjortkjær; Philip Brainin; Nicholas Carlson; Ellen Linnea Freese Ballegaard; Anne-Lise Kamper; Christina Christoffersen; Bo Feldt-Rasmussen; Klaus Fuglsang Kofoed; Susanne Bro Journal: BMC Nephrol Date: 2020-12-09 Impact factor: 2.388
Authors: Jens Christian Laursen; Ida Kirstine B Rasmussen; Emilie H Zobel; Philip Hasbak; Bernt Johan von Scholten; Lene Holmvang; Rasmus S Ripa; Christian S Hansen; Marie Frimodt-Moeller; Andreas Kjaer; Peter Rossing; Tine W Hansen Journal: Front Endocrinol (Lausanne) Date: 2021-12-13 Impact factor: 5.555
Authors: Sasha S Bjergfelt; Ida M H Sørensen; Henrik Ø Hjortkjær; Nino Landler; Ellen L F Ballegaard; Tor Biering-Sørensen; Klaus F Kofoed; Theis Lange; Bo Feldt-Rasmussen; Henrik Sillesen; Christina Christoffersen; Susanne Bro Journal: PLoS One Date: 2021-11-23 Impact factor: 3.240