Yunshan Zhou1, Xiuru Wang2, Yuan An1, Xiaoying Zhang1, Shuling Han3, Xiaofeng Li4, Lizhi Wang4, Caihong Wang4, Yongfu Wang5, Rong Yang5, Guochun Wang6, Xin Lu6, Ping Zhu7, Lina Chen7, Jinting Liu8, Hongtao Jin8, Xiangyuan Liu9, Lin Sun9, Ping Wei10, Junxiang Wang10, Haiying Chen10, Liufu Cui11, Rong Shu11, Zhuoli Zhang12, Guangtao Li12, Zhenbin Li13, Jing Yang13, Junfang Li14, Bin Jia14, Fengxiao Zhang15, Jiemei Tao15, Jinying Lin16, Qiumei Wei16, Xiaomin Liu17, Dan Ke17, Shaoxian Hu18, Cong Ye18, Xiuyan Yang19, Hao Li19, Cibo Huang20, Ming Gao20, Xingfu Li21, Lijun Song21, Yi Wang22, Xiaoyuan Wang22, Rong Mu1, Yin Su1, Zhanguo Li1. 1. Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. 2. Duoding Street Community Health Center, Peking University Shougang Hospital, Beijing, China. 3. Department of Rheumatology and Immunology, Peking University Shougang Hospital, Beijing, China. 4. Department of Rheumatology and Immunology, Second Hospital of Shanxi Medical University, Taiyuan, China. 5. Department of Rheumatology and Immunology, The First Affiliated Hospital, Baotou Medical College, Baotou, China. 6. Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China. 7. Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. 8. Department of Rheumatology and Immunology, Second Hospital of Hebei Medical University, Shijiazhuang, China. 9. Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China. 10. Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, Shijiazhuang, China. 11. Department of Rheumatology and Immunology, The Affiliated Kailuan Hospital of North China Coal Medical University, Tangshan, China. 12. Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China. 13. Department of Rheumatology and Immunology, Bethune International Peace Hospital of PLA, Shijiazhuang, China. 14. Department of Rheumatology and Immunology, Handan Central Hospital, Handan, China. 15. Department of Rheumatology and Immunology, The People's Hospital of Hebei Province, Shijiazhuang, China. 16. Department of Rheumatology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. 17. Department of Rheumatology and Immunology, Beijing Shunyi Hospital, Beijing, China. 18. Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 19. Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 20. Department of Rheumatology and Immunology, Beijing Hospital, Beijing, China. 21. Department of Rheumatology, Shandong University Qilu Hospital, Jinan, China. 22. Department of Rheumatology, Second Hospital of Lanzhou University, Lanzhou, China.
Abstract
AIM: The objective of this study was to evaluate the impact of rheumatoid arthritis (RA) on physical function and health-related quality of life (HRQoL) in China. METHOD: A cross-section survey was conducted in 21 general hospitals in China. Eight hundred and seven patients were recruited. Data on demographics, clinical data, physical function (Stanford Health Assessment Questionnaire Disability Index, HAQ-DI) and HRQoL (Study Short Form 36 Health Survey, SF-36) were collected on site. RESULTS: In our cohort, physical function was impaired in 77.6% of patients (HAQ-DI >0). The median (interquartile range, IQR) of HAQ-DI was 0.750 (0.125, 1.500). Rated by HAQ-DI 0-1, >1-2, and >2-3, percentage of patients with mild, moderate and severe disability was 61.0%, 25.4%, and 13.6%, respectively. Older age, long disease duration, presence of extra-articular manifestations, tender joint count (TJC), overall status (assessed by patient Global Visual Analogue Scale [G-VAS] and physician G-VAS) and lacking disease-modifying anti-rheumatic drugs were identified as predictive factors for worse physical function (P < .05). The composite scores of SF-36 in the observed patients were: physical component summary 40.4 (IQR 27.4, 60.3), and mental component summary 49.0 (IQR 33.6, 70.9). Impaired physical health may be predicted by low income, presence of extra-articular manifestations, TJC, patient G-VAS and high HAQ-DI. Predictors for suboptimal mental health were low income, physical labor, married status, increased swollen joint count (SJC), physician G-VAS and high HAQ-DI. CONCLUSION: Rheumatoid arthritis has profound effects on physical function and HRQoL in Chinese patients. Patients with identified predictive factors for poor outcome should be closely monitored.
AIM: The objective of this study was to evaluate the impact of rheumatoid arthritis (RA) on physical function and health-related quality of life (HRQoL) in China. METHOD: A cross-section survey was conducted in 21 general hospitals in China. Eight hundred and seven patients were recruited. Data on demographics, clinical data, physical function (Stanford Health Assessment Questionnaire Disability Index, HAQ-DI) and HRQoL (Study Short Form 36 Health Survey, SF-36) were collected on site. RESULTS: In our cohort, physical function was impaired in 77.6% of patients (HAQ-DI >0). The median (interquartile range, IQR) of HAQ-DI was 0.750 (0.125, 1.500). Rated by HAQ-DI 0-1, >1-2, and >2-3, percentage of patients with mild, moderate and severe disability was 61.0%, 25.4%, and 13.6%, respectively. Older age, long disease duration, presence of extra-articular manifestations, tender joint count (TJC), overall status (assessed by patient Global Visual Analogue Scale [G-VAS] and physician G-VAS) and lacking disease-modifying anti-rheumatic drugs were identified as predictive factors for worse physical function (P < .05). The composite scores of SF-36 in the observed patients were: physical component summary 40.4 (IQR 27.4, 60.3), and mental component summary 49.0 (IQR 33.6, 70.9). Impaired physical health may be predicted by low income, presence of extra-articular manifestations, TJC, patient G-VAS and high HAQ-DI. Predictors for suboptimal mental health were low income, physical labor, married status, increased swollen joint count (SJC), physician G-VAS and high HAQ-DI. CONCLUSION:Rheumatoid arthritis has profound effects on physical function and HRQoL in Chinese patients. Patients with identified predictive factors for poor outcome should be closely monitored.
Authors: Daniel Pankowski; Kinga Wytrychiewicz-Pankowska; Ewa Pisula; Andrzej Fal; Bartłomiej Kisiel; Ewa Kamińska; Witold Tłustochowicz Journal: Int J Environ Res Public Health Date: 2022-03-07 Impact factor: 3.390