Murat Ulu1, Nükhet Kütük2, Muhammet Furkan Cıcık3, Suheyb Bilge4, Hüseyin Akçay5, Suna Saygılı6, Mehmet İbrahim Tuğlu7, Alper Alkan2. 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University, Aydinlikevler District Cemil Meric St. 6780 St., 35640, Cigli, Izmir, Turkey. muratulu81@hotmail.com. 2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem University, 34093, Istanbul, Turkey. 3. Oral and maxillofacial surgeon, private practitioner, 35640, Izmir, Turkey. 4. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, 38039, Kayseri, Turkey. 5. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University, Aydinlikevler District Cemil Meric St. 6780 St., 35640, Cigli, Izmir, Turkey. hus_akcay@yahoo.com. 6. Department of Histology and Embryology, Faculty of Medicine, T.C. Kütahya Sağlık Bilimleri University, 43100, Kütahya, Turkey. 7. Department of Histology and Embryology, Faculty of Medicine, Manisa Celal Bayar University, 45030, Manisa, Turkey.
Abstract
PURPOSE: Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA). MATERIALS AND METHODS: Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3. RESULTS: The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05). CONCLUSION: Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
PURPOSE: Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA). MATERIALS AND METHODS: Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3. RESULTS: The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05). CONCLUSION: Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
Entities:
Keywords:
Bone regeneration; Boric acid; Immunohistochemistry; Rabbit; Sinus floor augmentation
Authors: D Rickert; J J R Huddleston Slater; H J A Meijer; A Vissink; G M Raghoebar Journal: Int J Oral Maxillofac Surg Date: 2011-11-17 Impact factor: 2.789