| Literature DB >> 30344894 |
Yaqiong Chai1,2,3, Jieshen Chen1,4, Cristina Galarza1,5, Maayke A Sluman6, Botian Xu1,4, Chau Q Vu2,3, Edo Richard7, Barbara Mulder6, Benita Tamrazi3, Natasha Lepore1,2,3, Henri J M M Mutsaerts8,9, John C Wood10.
Abstract
Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.Entities:
Keywords: Tetralogy of Fallot; arterial spin labeling; cerebral blood flow; deep white matter lesion
Year: 2018 PMID： 30344894 PMCID： PMC6192027 DOI： 10.1109/ISBI.2018.8363812
Source DB: PubMed Journal: Proc IEEE Int Symp Biomed Imaging ISSN： 1945-7928