Literature DB >> 30344790

Langerhans' Cell Histiocytosis Masquerading as Metastatic Papillary Thyroid Cancer on F-18 FDG PET/CT: Diagnostic Dilemma Solved by PET/CT-Guided Biopsy.

Dharmender Malik1, Rajender Kumar1, Bhagwant Rai Mittal1, Gaurav Parkash2, Amanjit Bal3, Anish Bhattacharya1.   

Abstract

We present a case of papillary thyroid cancer (post-thyroidectomy status) on regular treatment with suppressive Levothyroxine therapy. On follow-up at 6 months after radioactive iodine ablation for remnant thyroid tissue, her thyroglobulin, and anti-thyroglobulin levels were 0.06 ng/ml and 670 IU/ml, respectively. Low-dose whole-body I-131 scan was negative. To look for the cause of isolated increased anti-thyroglobulin level, a whole-body 18F-FDG PET/CT was done which revealed multiple FDG-avid lytic skeletal lesions suggestive of metastases. For confirmation of diagnosis, 18F-FDG PET/CT-guided metabolic biopsy was done, which revealed Langerhans' cell histiocytosis on histopathological examination.

Entities:  

Keywords:  18F-FDG PET/CT; Anti-thyroglobulin level; Langerhans’ cell histiocytosis; PET/CT-guided biopsy; Papillary thyroid cancer

Year:  2018        PMID： 30344790      PMCID： PMC6177344          DOI： 10.1007/s13139-018-0536-7

Source DB:  PubMed          Journal:  Nucl Med Mol Imaging        ISSN： 1869-3474


  14 in total

Review 1.  Solitary langerhans histiocytosis of the thyroid gland: a case report and literature review.

Authors:  Darren K Patten; Zubair Wani; Neil Tolley
Journal:  Head Neck Pathol       Date:  2011-12-24

2.  Increasing incidence of thyroid cancer in the United States, 1973-2002.

Authors:  Louise Davies; H Gilbert Welch
Journal:  JAMA       Date:  2006-05-10       Impact factor: 56.272

3.  Diagnosis and treatment of pancreatic metastases of a papillary thyroid carcinoma.

Authors:  Thomas Borschitz; Waltraud Eichhorn; Christian Fottner; Torsten Hansen; Arno Schad; Simin Schadmand-Fischer; Matthias M Weber; Mathias Schreckenberger; Hauke Lang; Thomas J Musholt
Journal:  Thyroid       Date:  2010-01       Impact factor: 6.568

4.  Recurrent BRAF mutations in Langerhans cell histiocytosis.

Authors:  Gayane Badalian-Very; Jo-Anne Vergilio; Barbara A Degar; Laura E MacConaill; Barbara Brandner; Monica L Calicchio; Frank C Kuo; Azra H Ligon; Kristen E Stevenson; Sarah M Kehoe; Levi A Garraway; William C Hahn; Matthew Meyerson; Mark D Fleming; Barrett J Rollins
Journal:  Blood       Date:  2010-06-02       Impact factor: 22.113

5.  Papillary thyroid carcinoma with distant metastases: survival predictors and the importance of local control.

Authors:  Iwao Sugitani; Yoshihide Fujimoto; Noriko Yamamoto
Journal:  Surgery       Date:  2007-12-03       Impact factor: 3.982

6.  Fine-needle aspiration of primary Langerhans cell histiocytosis of the thyroid gland, a potential mimic of papillary thyroid carcinoma.

Authors:  Marc P Pusztaszeri; Kenan J Sauder; Edmund S Cibas; William C Faquin
Journal:  Acta Cytol       Date:  2013-07-10       Impact factor: 2.319

7.  Prognostic factors in patients with well-differentiated thyroid cancer presenting with pulmonary metastasis.

Authors:  Timothy N Showalter; Barry A Siegel; Jeffrey F Moley; Thomas J Baranski; Perry W Grigsby
Journal:  Cancer Biother Radiopharm       Date:  2008-10       Impact factor: 3.099

8.  Differentiated thyroid carcinoma with distant metastases: probability of survival and its predicting factors.

Authors:  Jasna Mihailovic; Ljubomir Stefanovic; Milica Malesevic
Journal:  Cancer Biother Radiopharm       Date:  2007-04       Impact factor: 3.099

9.  Mutations of the BRAF gene in human cancer.

Authors:  Helen Davies; Graham R Bignell; Charles Cox; Philip Stephens; Sarah Edkins; Sheila Clegg; Jon Teague; Hayley Woffendin; Mathew J Garnett; William Bottomley; Neil Davis; Ed Dicks; Rebecca Ewing; Yvonne Floyd; Kristian Gray; Sarah Hall; Rachel Hawes; Jaime Hughes; Vivian Kosmidou; Andrew Menzies; Catherine Mould; Adrian Parker; Claire Stevens; Stephen Watt; Steven Hooper; Rebecca Wilson; Hiran Jayatilake; Barry A Gusterson; Colin Cooper; Janet Shipley; Darren Hargrave; Katherine Pritchard-Jones; Norman Maitland; Georgia Chenevix-Trench; Gregory J Riggins; Darell D Bigner; Giuseppe Palmieri; Antonio Cossu; Adrienne Flanagan; Andrew Nicholson; Judy W C Ho; Suet Y Leung; Siu T Yuen; Barbara L Weber; Hilliard F Seigler; Timothy L Darrow; Hugh Paterson; Richard Marais; Christopher J Marshall; Richard Wooster; Michael R Stratton; P Andrew Futreal
Journal:  Nature       Date:  2002-06-09       Impact factor: 49.962

10.  Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level.

Authors:  Zhong-Ling Qiu; Wei-Jun Wei; Chen-Tian Shen; Hong-Jun Song; Xin-Yun Zhang; Zhen-Kui Sun; Quan-Yong Luo
Journal:  Sci Rep       Date:  2017-06-06       Impact factor: 4.379
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  3 in total

1.  Application of 18F-FDG PET/CT in Langerhans Cell Histiocytosis.

Authors:  Fengxiang Liao; Zhehuang Luo; Zizhen Huang; Rong Xu; Wanling Qi; Mingyan Shao; Pinggui Lei; Bing Fan
Journal:  Contrast Media Mol Imaging       Date:  2022-08-19       Impact factor: 3.009

2.  Analysis of thyroid involvement in children and adult Langerhans cell histiocytosis: An underestimated endocrine manifestation.

Authors:  Yuanmeng Li; Long Chang; Xiaofeng Chai; He Liu; Hongbo Yang; Yu Xia; Li Huo; Hui Zhang; Naishi Li; Xiaolan Lian
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-30       Impact factor: 6.055

Review 3.  Spontaneous Thyroid Hemorrhage Caused by Langerhans Cell Histiocytosis: A Case Report and Literature Review.

Authors:  Jingying Zhang; Chengchen Wang; Chuanshuai Lin; Binglong Bai; Mao Ye; Dapeng Xiang; Zhiyu Li
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-19       Impact factor: 5.555
  3 in total

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