J Enrique Dominguez-Munoz1, Asbjørn M Drewes2, Björn Lindkvist3, Nils Ewald4, László Czakó5, Jonas Rosendahl6, J Matthias Löhr7. 1. Department of Gastroenterology and Hepatology, Health Research Institute, University Hospital of Santiago de Compostela, Spain. Electronic address: Juan.Enrique.Dominguez.Munoz@sergas.es. 2. Centre for Pancreatic Diseases, Department of Gastroenterology, Aalborg University Hospital, Denmark. 3. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 4. Department of Internal Medicine, General Hospital Luebbecke-Rahden, Luebbecke, Justus Liebig University Giessen, Giessen, Germany. 5. First Department of Medicine, University of Szeged, Szeged, Hungary. 6. Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany. 7. Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Abstract
BACKGROUND: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. METHODS: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system. RESULTS: Recommendations covered topics related to the clinical management of chronic pancreatitis: aetiology, diagnosis of chronic pancreatitis with imaging, diagnosis of pancreatic exocrine insufficiency, surgical therapy, medical therapy, endoscopic therapy, treatment of pancreatic pseudocysts, pancreatic pain, nutrition and malnutrition, diabetes mellitus and the natural course of the disease and quality of life. CONCLUSIONS: The HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research. This article summarises the HaPanEU recommendations and statements.
BACKGROUND: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. METHODS: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system. RESULTS: Recommendations covered topics related to the clinical management of chronic pancreatitis: aetiology, diagnosis of chronic pancreatitis with imaging, diagnosis of pancreatic exocrine insufficiency, surgical therapy, medical therapy, endoscopic therapy, treatment of pancreatic pseudocysts, pancreatic pain, nutrition and malnutrition, diabetes mellitus and the natural course of the disease and quality of life. CONCLUSIONS: The HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research. This article summarises the HaPanEU recommendations and statements.
Keywords:
Chronic pancreatitis; Development and evaluation (GRADE); Diabetes mellitus; Endoscopic therapy; Grading of recommendations assessment; Guidelines; Pain; Pancreatic exocrine insufficiency; Pseudocyst; Quality of life
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