| Literature DB >> 30343952 |
Joaquim Gea1, Sergi Pascual2, Ady Castro-Acosta3, Carmen Hernández-Carcereny4, Robert Castelo5, Eduardo Márquez-Martín6, Concepción Montón7, Alexandre Palou8, Rosa Faner4, Laura I Furlong5, Luis Seijo9, Ferran Sanz5, Montserrat Torà10, Carles Vilaplana11, Carme Casadevall2, José Luis López-Campos6, Eduard Monsó7, Germán Peces-Barba12, Borja G Cosío8, Alvar Agustí4.
Abstract
Chronic obstructive pulmonary disease (COPD) is an entity with a heterogeneous presentation. For this reason, attempts have been made to characterize different phenotypes and endotypes to enable a more individualized approach. The aim of the Biomarkers in COPD (BIOMEPOC) project is to identify useful biomarkers in blood to improve the characterization of patients. Clinical data and blood samples from a group of patients and healthy controls will be analyzed. The project will consist of an exploration phase and a validation phase. Analytical parameters in blood will be determined using standard techniques and certain 'omics' (transcriptomics, proteomics, and metabolomics). The former will be hypothesis-driven, whereas the latter will be exploratory. Finally, a multilevel analysis will be conducted. Currently, 269 patients and 83 controls have been recruited, and sample processing is beginning. Our hope is to use the results to identify new biomarkers that, alone or combined, will allow a better characterization of patients.Entities:
Keywords: Análisis multinivel; Biological markers; COPD; EPOC; Endotipos; Endotypes; Marcadores biológicos; Medicina personalizada; Multilevel analysis; Personalized medicine
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Year: 2018 PMID： 30343952 DOI： 10.1016/j.arbres.2018.07.026
Source DB: PubMed Journal: Arch Bronconeumol (Engl Ed) ISSN： 0300-2896 Impact factor: 4.872