Michael C Burke1, Ankur Garg2, Jonathan M Youngner2, Swati D Deshmukh2, Imran M Omar2. 1. Department of Radiology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 800, Chicago, IL, 60611, USA. michael.c.burke.85@gmail.com. 2. Department of Radiology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 800, Chicago, IL, 60611, USA.
Abstract
OBJECTIVE: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scintigraphy, or positron-emission tomography/computed tomography (PET/CT), but occult on monoenergetic computed tomography (CT) by virtue of being either isodense or nearly isodense to surrounding normal bone. MATERIALS AND METHODS: We present 4 cases in which DECT was used to detect various malignant bone lesions and was successfully used to direct percutaneous DECT-guided bone biopsies. RESULTS: Two of the lesions were solid tumor metastases (breast and prostate carcinoma), whereas two others were hematological malignancies (leukemia and lymphoma). This technique enabled us to confidently and accurately direct the biopsy needle into the target lesion. CONCLUSION: The authors demonstrate that the DECT VNCa bone marrow algorithm may be helpful in identifying isodense bone lesions of various histologies and may be used to guide percutaneous bone biopsies. This technique may help to maximize diagnostic yield, minimize the number of passes into the region of concern, and prevent patients from undergoing repeat biopsy.
OBJECTIVE: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scintigraphy, or positron-emission tomography/computed tomography (PET/CT), but occult on monoenergetic computed tomography (CT) by virtue of being either isodense or nearly isodense to surrounding normal bone. MATERIALS AND METHODS: We present 4 cases in which DECT was used to detect various malignant bone lesions and was successfully used to direct percutaneous DECT-guided bone biopsies. RESULTS: Two of the lesions were solid tumor metastases (breast and prostate carcinoma), whereas two others were hematological malignancies (leukemia and lymphoma). This technique enabled us to confidently and accurately direct the biopsy needle into the target lesion. CONCLUSION: The authors demonstrate that the DECT VNCa bone marrow algorithm may be helpful in identifying isodense bone lesions of various histologies and may be used to guide percutaneous bone biopsies. This technique may help to maximize diagnostic yield, minimize the number of passes into the region of concern, and prevent patients from undergoing repeat biopsy.
Entities:
Keywords:
Bone biopsy; Dual-energy CT; Isodense bone lesion
Authors: John A Carrino; Bharti Khurana; John E Ready; Stuart G Silverman; Carl S Winalski Journal: J Bone Joint Surg Am Date: 2007-10 Impact factor: 5.284
Authors: Eugenio Rimondi; Eric L Staals; Costantino Errani; Giuseppe Bianchi; Roberto Casadei; Marco Alberghini; Maria Cristina Malaguti; Giuseppe Rossi; Stefano Durante; Mario Mercuri Journal: Eur Spine J Date: 2008-05-08 Impact factor: 3.134
Authors: Leandro A Espinosa; David A Jamadar; Jon A Jacobson; Michel O DeMaeseneer; Farhad S Ebrahim; Brian J Sabb; Matthew T Kretschmer; Janet S Biermann; Sung-Moon Kim Journal: AJR Am J Roentgenol Date: 2008-05 Impact factor: 3.959
Authors: Warapat Virayavanich; Michael D Ringler; Cynthia T Chin; Thomas Baum; Joseph C Giaconi; Richard J O'Donnell; Andrew E Horvai; Kirk D Jones; Thomas M Link Journal: J Vasc Interv Radiol Date: 2011-05-14 Impact factor: 3.464
Authors: Katrina N Glazebrook; Luis S Guimarães; Naveen S Murthy; David F Black; Tim Bongartz; Nisha J Manek; Shuai Leng; Joel G Fletcher; Cynthia H McCollough Journal: Radiology Date: 2011-09-16 Impact factor: 11.105
Authors: Sinchun Hwang; Robert A Lefkowitz; Jonathan Landa; Junting Zheng; Chaya S Moskowitz; Majid Maybody; Meera Hameed; David M Panicek Journal: AJR Am J Roentgenol Date: 2011-12 Impact factor: 3.959
Authors: Eugenio Rimondi; Giuseppe Rossi; Tommaso Bartalena; Rosanna Ciminari; Marco Alberghini; Pietro Ruggieri; Costantino Errani; Andrea Angelini; Teresa Calabrò; Caterina Novella Abati; Alba Balladelli; Cristina Tranfaglia; Andreas F Mavrogenis; Daniel Vanel; Mario Mercuri Journal: Eur J Radiol Date: 2010-09-15 Impact factor: 3.528
Authors: Michelle C Omura; Kambiz Motamedi; Stacy UyBico; Scott D Nelson; Leanne L Seeger Journal: AJR Am J Roentgenol Date: 2011-08 Impact factor: 3.959
Authors: Francis I Baffour; Katrina N Glazebrook; Jonathan M Morris; Gregory J Michalak; Joel G Fletcher; Shuai Leng; Cynthia H McCollough Journal: Skeletal Radiol Date: 2019-05-30 Impact factor: 2.199
Authors: Philipp Fervers; Florian Fervers; Jonathan Kottlors; Philipp Lohneis; Philip Pollman-Schweckhorst; Hasan Zaytoun; Miriam Rinneburger; David Maintz; Nils Große Hokamp Journal: Eur Radiol Date: 2021-12-18 Impact factor: 7.034
Authors: Tommaso D'Angelo; Moritz H Albrecht; Danilo Caudo; Silvio Mazziotti; Thomas J Vogl; Julian L Wichmann; Simon Martin; Ibrahim Yel; Giorgio Ascenti; Vitali Koch; Giuseppe Cicero; Alfredo Blandino; Christian Booz Journal: Eur Radiol Exp Date: 2021-09-03