Alisson R Teles1, Don Daniel Ocay2, Abdulaziz Bin Shebreen3, Andrew Tice3, Neil Saran4, Jean A Ouellet5, Catherine E Ferland6. 1. Integrated Program in Neurosciences, McGill University, Montreal, Québec, Canada; McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Alan Edwards Centre for Research on Pain, Montreal, Québec, Canada. 2. McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Alan Edwards Centre for Research on Pain, Montreal, Québec, Canada. 3. McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada. 4. McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Division of Pediatric Orthopaedics, McGill University, Montreal, Québec, Canada. 5. McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Alan Edwards Centre for Research on Pain, Montreal, Québec, Canada; Division of Pediatric Orthopaedics, McGill University, Montreal, Québec, Canada. 6. Integrated Program in Neurosciences, McGill University, Montreal, Québec, Canada; McGill Scoliosis and Spine Group, Montreal, Québec, Canada; Shriners Hospital for Children-Canada, Montreal, Québec, Canada; McGill University Health Centre, Montreal, Québec, Canada; Alan Edwards Centre for Research on Pain, Montreal, Québec, Canada; Department of Anesthesia, McGill University, Montreal, Québec, Canada. Electronic address: catherine.ferland@mcgill.ca.
Abstract
BACKGROUND CONTEXT: Although 40% of adolescent idiopathic scoliosis (AIS) patients present with chronic back pain, the pathophysiology and underlying pain mechanisms remain poorly understood. We hypothesized that development of chronic pain syndrome in AIS is associated with alterations in pain modulatory mechanisms. PURPOSE: To identify the presence of sensitization in nociceptive pathways and to assess the efficacy of the diffuse noxious inhibitory control in patients with AIS presenting with chronic back pain. STUDY DESIGN: Cross-sectional study. PATIENT SAMPLE: Ninety-four patients diagnosed with AIS and chronic back pain. OUTCOME MEASURES: Quantitative sensory testing (QST) assessed pain modulation and self-reported questionnaires were used to assess pain burden and health-related quality of life. METHODS: Patients underwent a detailed pain assessment using a standard and validated quantitative sensory testing (QST) protocol. The measurements included mechanical detection thresholds (MDT), pain pressure threshold (PPT), heat pain threshold (HPT), heat tolerance threshold (HTT), and a conditioned pain modulation (CPM) paradigm. Altogether, these tests measured changes in regulation of the neurophysiology underlying the nociceptive processes based on the patient's pain perception. Funding was provided by The Louise and Alan Edwards Foundation and The Shriners Hospitals for Children. RESULTS: Efficient pain inhibitory response was observed in 51.1% of patients, while 21.3% and 27.7% had sub-optimal and inefficient CPM, respectively. Temporal summation of pain was observed in 11.7% of patients. Significant correlations were observed between deformity severity and pain pressure thresholds (p=.023) and CPM (p=.017), neuropathic pain scores and pain pressure thresholds (p=.015) and temporal summation of pain (p=.047), and heat temperature threshold and pain intensity (p=.048). CONCLUSIONS: Chronic back pain has an impact in the quality of life of adolescents with idiopathic scoliosis. We demonstrated a high prevalence of impaired pain modulation in this group. The association between deformity severity and somatosensory dysfunction may suggest that spinal deformity can be a trigger for abnormal neuroplastic changes in this population contributing to chronic pain syndrome.
BACKGROUND CONTEXT: Although 40% of adolescent idiopathic scoliosis (AIS) patients present with chronic back pain, the pathophysiology and underlying pain mechanisms remain poorly understood. We hypothesized that development of chronic pain syndrome in AIS is associated with alterations in pain modulatory mechanisms. PURPOSE: To identify the presence of sensitization in nociceptive pathways and to assess the efficacy of the diffuse noxious inhibitory control in patients with AIS presenting with chronic back pain. STUDY DESIGN: Cross-sectional study. PATIENT SAMPLE: Ninety-four patients diagnosed with AIS and chronic back pain. OUTCOME MEASURES: Quantitative sensory testing (QST) assessed pain modulation and self-reported questionnaires were used to assess pain burden and health-related quality of life. METHODS:Patients underwent a detailed pain assessment using a standard and validated quantitative sensory testing (QST) protocol. The measurements included mechanical detection thresholds (MDT), pain pressure threshold (PPT), heat pain threshold (HPT), heat tolerance threshold (HTT), and a conditioned pain modulation (CPM) paradigm. Altogether, these tests measured changes in regulation of the neurophysiology underlying the nociceptive processes based on the patient's pain perception. Funding was provided by The Louise and Alan Edwards Foundation and The Shriners Hospitals for Children. RESULTS: Efficient pain inhibitory response was observed in 51.1% of patients, while 21.3% and 27.7% had sub-optimal and inefficient CPM, respectively. Temporal summation of pain was observed in 11.7% of patients. Significant correlations were observed between deformity severity and pain pressure thresholds (p=.023) and CPM (p=.017), neuropathic pain scores and pain pressure thresholds (p=.015) and temporal summation of pain (p=.047), and heat temperature threshold and pain intensity (p=.048). CONCLUSIONS:Chronic back pain has an impact in the quality of life of adolescents with idiopathic scoliosis. We demonstrated a high prevalence of impaired pain modulation in this group. The association between deformity severity and somatosensory dysfunction may suggest that spinal deformity can be a trigger for abnormal neuroplastic changes in this population contributing to chronic pain syndrome.
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