| Literature DB >> 30342546 |
Elisabeth Hodille1,2, Cédric Badiou3, Caroline Bouveyron4,5, Michèle Bes4,5,3, Anne Tristan4,5,3, François Vandenesch4,5,3, Gérard Lina4,5,3, Oana Dumitrescu4,5,3.
Abstract
Clindamycin is a protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus. Recent guidelines recommend the use of clindamycin for the treatment of toxin-mediated infections. Clindamycin modulates virulence expression at sub-inhibitory concentrations (sub-MICs) in clindamycin-susceptible S. aureus strains but previous report shown that this effect was supressed for constitutive clindamycin resistant strains. However, no data are currently available on the impact of clindamycin at sub-MICs on the virulence of inducible clindamycin-resistant S. aureus strains. Here, we show that sub-MICs of clindamycin decrease Panton-Valentine leucocidin, toxic-shock-staphylococcal toxin (TSST-1) and alpha-haemolysin (Hla) expression in six inducible clindamycin-resistant isolates cultivated in vitro in CCY medium. These results suggest that the clindamycin anti-toxin effect is retained for inducible clindamycin-resistant S. aureus isolates; therefore, its usage should be considered within the treatment regimen of toxin related infections for inducible clindamycin-resistant S. aureus.Entities:
Keywords: Alpha-haemolysin; Anti-toxin effect; Inducible clindamycin resistance; Panton–Valentine leucocidin; Staphylococcus aureus; Toxic-shock-staphylococcal toxin
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Year: 2018 PMID： 30342546 PMCID： PMC6195712 DOI： 10.1186/s12941-018-0291-8
Source DB: PubMed Journal: Ann Clin Microbiol Antimicrob ISSN： 1476-0711 Impact factor: 3.944